Research Associate, Postdoctoral researcher, positions available to work Dr. Kanaan on tau protein biology and pathobiology, as well as Alzheimer's disease, other tauopathies and models of tauopathy. Dr. Kanaan is in the Department of Translational Neuroscience at MSU, which is home to a collaborative and active group of investigators with a strong focus on aging and neurodegenerative diseases (translationalscience.msu.edu/default.htm). Applicants must apply to job posting #639687 at: https://careers.msu.edu/mob/en-us/job/503458/research-associatefixed-term.
The Research Associate, Postdoctoral Researcher, will be expected to develop a research project that is focused on aspects of tau biology and pathobiology, with an emphasis on molecular mechanisms underlying neuronal dysfunction and degeneration in the context of Alzheimer's disease and other tauopathies. Opportunities exist to study this area through a diverse set of approaches and model systems. Ongoing funded projects include:
molecular mechanisms of tau-mediated neuronal toxicity,
impact of post-translational modifications and pathogenic conformational changes in tau protein,
use of rodent models to study tau's role in dysfunction and degeneration,
use of post-mortem human tissue samples to identify key pathological changes in tau,
the development of novel tau biomarker assays for biofluids,
generation of novel monoclonal antibodies against specific forms of tau and other target proteins of interest.
The projects involve expertise in advanced molecular, biochemical, histological, and microscopy techniques, as well as in vitro cell culture and in vivo animal model techniques.
Duties will include:
helping in the day-to-day operations of the lab,
collaborative experimental design,
conducting independent research,
presenting data at conferences,
writing manuscripts for publication in peer-reviewed journals.
The applicant will also gain exposure in mentoring graduate students and have the opportunity to explore career options.
This position is located in the vibrant city of Grand Rapids, MI, (www.experiencegr.com) in the MSU Grand Rapids Research Center (GRRC), a state of the art research facility. The GRRC is located on the Medical Mile (www.experiencegr.com/about-grand-rapids/neighborhoods/medical-mile/) where MSU and other local community partners are driving innovation and discovery in many facets of biomedical research.
The position requires a doctoral degree in a biomedical research discipline which included at least 4 years of experience in a research laboratory.
Individual should be familiar with common biological laboratory research techniques and have an understanding of neurobiology, biochemistry, molecular biology, cell biology, physiology, animal and cell modeling, and/or neurodegenerative disease biology.
Applicants should be able to demonstrate his or her critical thinking skills, experience independently conducting research studies, fundamental statistical analysis, and the preparation of results for publication as a scientific manuscript and presentations at scientific conferences.
The applicant must work well in a team-oriented environment.
At least one first author paper in a peer-reviewed journal is expected.
Good command of spoken and written English is a requirement.
Training in the discipline of neuroscience with a focus on molecular neuroscience, neurological diseases (e.g. the field of Alzheimer's disease and tauopathies) and/or protein misfolding is highly desired.
Experience with one or more of the following research areas/sets of techniques is also highly desired:
advanced molecular biology and protein biochemistry techniques such as cloning, gene regulation, recombinant protein, protein and post-translational modification analyses, gene knockdown approaches;
cell culture modeling and analysis, including immortal cell lines and rodent primary neuron cultures, live-cell imaging, transfection and/or viral transduction, and synaptic analyses;
small rodent studies, including husbandry, stereotaxic surgical procedures, behavioral (motor and/or cognitive) analyses, gene therapy-based approaches to express or knockdown genes, and necropsy;
human and rodent tissue processing, fresh tissue biochemistry assays and fixed tissue immunohistochemical assays (including multi-label immunoflourescence);
advanced microscopy techniques, including stereological analysis, transmission electron microscopy, confocal microscopy, super-resolution microscopy and/or standard brightfield/fluorescence microscopy; and/or
monoclonal antibody production, validation and application in biochemical and immunohistological assays.
All applicants should have an understanding and experience applying statistical analysis including familiarity with Prism, R or similar statistical computing programs are a benefit.
Highly competitive applicants will have multiple authorships including at least 1-3 first-author manuscript in a peer-reviewed journal.
Required Application Materials
Curriculum Vitae, Names of 3 or more references, 1-2 page statement highlighting past accomplishments and future research and career goals. Submit applications to job posting #639687 at: https://careers.msu.edu/mob/en-us/job/503458/research-associatefixed-term
Internal Number: 639687
About Michigan State University
MSU Mission Statement:
Michigan State University, a member of the Association of American Universities and one of the top 100 research universities in the world, was founded in 1855. We are an inclusive, academic community known for our traditionally strong academic disciplines and professional programs, and our liberal arts foundation. Our cross- and interdisciplinary enterprises connect the sciences, humanities, and professions in practical, sustainable, and innovative ways to address society’s rapidly changing needs.
As a public, research-intensive, land-grant university funded in part by the state of Michigan, our mission is to advance knowledge and transform lives by:
1) providing outstanding undergraduate, graduate, and professional education to promising, qualified students in order to prepare them to contribute fully to society as globally engaged citizen leaders
2) conducting research of the highest caliber that seeks to answer questions and create solutions in order to expand human understanding and make a positive difference, both locally and globally
3) advancing outreach, engagement, and economic development activities that are innovative, research-driven, and l...ead to a better quality of life for individuals and communities, at home and around the world
The MSU Mission Statement was approved by the Board of Trustees on April 18, 2008.
MSU is an affirmative-action, equal-opportunity employer.
These postdoctoral Fellow positions will work under the mentorship/supervision of Dr. Nicholas Kanaan, Department of Translational Neuroscience, College of Human Medicine at MSU's Grand Rapids Research Center located in the heart of Grand Rapids, MI.
Dr. Kanaan's MSU Faculty Website (http://translationalscience.msu.edu/people/NMKfaculty.htm)
Dr. Kanaan's MSU Lab Website (http://translationalscience.msu.edu/research/NMKlab.htm)
Department of Translational Neuroscience Website (http://translationalscience.msu.edu)