The laboratory of Ethan Goldberg (goldbergneurolab.com) at Children’s Hospital of Philadelphia and The University of Pennsylvania, in Philadelphia, PA, U.S.A., has a funded, open position for a postdoctoral fellow or research associate interested in studying mechanisms of epilepsy and neurodevelopmental disorders in experimental model systems.
Our research interests and approaches include:
The study of epilepsy-associated ion channel variants expressed in heterologous systems;
Electrophysiology, optogenetics, and imaging (2P calcium imaging and voltage imaging) in acute brain slices;
Modeling of human epilepsy syndromes in neurons and organoids derived from human induced pluripotent stem cells (iPSCs);
Treatment of epilepsy and modulation of cerebral cortical circuits in experimental models using GABAergic interneurons derived from mouse ES and human iPS cells;
Study of the mechanisms of seizure generation and propagation in awake, behaving experimental animal models of epilepsy in vivo using EEG, optogenetics, and two-photon calcium imaging.
Alterations in large-scale gene expression profiles in defined subsets of neurons in models of epilepsy
Selected recent publications include:
Goff KM, Goldberg EM. Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome. Elife. 2019 Jul 8;8. pii: e46846. doi: 10.7554/eLife.46846.
Zaman et al., 2018. Mutations in SCN3A cause early infantile epileptic encephalopathy. Annals of Neurology. 83(4):703-717.
Favero et al. 2018. A Transient Developmental Window of Fast-Spiking Interneuron Dysfunction in a Mouse Model of Dravet Syndrome. J Neurosci. 38(36):7912-7927.
About the Employer: Dr. Goldberg is Assistant Professor in the Departments of Neurology & Neuroscience at The Children’s Hospital of Philadelphia and The University of Pennsylvania and Director of the Epilepsy NeuroGenetics Initiative. The Children's Hospital of Philadelphia is located on the CHOP/UPenn campus and has a long and distinguished tradition of research that has spanned nearly a century. The University of Pennsylvania neuroscience community is a rich academic environment comprised of over 200 faculty with almost 100 neuroscience-related interest groups.
Interested individuals should send a brief cover letter, CV, and references and/or letters of recommendation to Dr. Goldberg at: firstname.lastname@example.org.
The successful applicant should be either:
A senior graduate student or recent graduate with a Ph.D. in neuroscience or related/applied field (physiology, electrical or biomedical engineering, computer science) who is seeking a postdoctoral fellowship position.
A postdoctoral fellow or research associate with a Ph.D. in neuroscience or related/applied field who is seeking a research associate position.
Prior experience with animal behavior, electrophysiology, imaging, single cell biology, and/or computational neuroscience, is required.
Internal Number: 4
About The Children's Hospital of Philadelphia
The Children's Hospital of Philadelphia has a long and distinguished tradition of research that has spanned nearly a century. The research breakthroughs at Children's Hospital have improved the lives of countless children throughout the world and put the institution on the course to pediatric research preeminence. Today, the Hospital's entire research enterprise is organized under the aegis of the CHOP Research Institute and constitutes a separate organizational, administrative and financial entity within the Hospital. CHOP is part of the larger University of Pennsylvania system which has a rich neuroscience community and shares a campus with the School of Engineering, School of Medicine, and the College of the University of Pennsylvania. While Research Institute investigators have academic homes in one of the Hospital's six departments and hold faculty appointments at the University of Pennsylvania, researchers also belong to designated Centers of Emphasis and interdisciplinary, cross-divisional Research Affinity Groups. These groups, as well as investigators and their research programs, are supported by more than a dozen Core Facilities that substantially enhance basic and clinic...al research programs. The cores provide investigators with sophisticated research equipment, knowledgeable advisors and experienced support staff. The Research Institute invests annually in refreshing the cores and acquiring new cutting-edge resources to ensure that investigators have access to the best tools available.
Today, The Children's Hospital of Philadelphia Research Institute is home to one of the largest pediatric research programs in the country with more than $138 million in total federal awards and an annual budget of more than $329 million (FY14).