We are seeking an enthusiastic postdoctoral fellow to join our multidisciplinary group dedicated to identifying biomarkers and potential pathogenic cargo from circulating extracellular vesicles after head injury and combat trauma. Protein and RNAs (including microRNAs) are detectable free or in extracellular vesicles (i.e. exosomes ...) in the biological fluids as stable molecules. The aim of this project is to study proteins (via multiplex and ELISA) and RNA (via RNA-seq) detected in circulating exosomes that are enriched for neuronal and astrocyte populations from patients that have experienced traumatic brain injury (TBI) and post-traumatic stress disorder. Our recent data have shown differential levels of proteins in circulating exosomes enriched for neuronal and astrocyte derivation in TBI vs. control subjects.
The objective of the present project is to characterize the protein and RNA cargo in circulating exosomes to develop potential non-invasive biomarkers for TBI and PTSD, and to better understand potential pathological consequences of exosome signaling.
Please send curriculum vitae and contact information for three references to: Victoria Risbrough, Ph.D., Dept. of Psychiatry, UCSD, 9500 Gilman Drive, La Jolla, CA 92093-0804; e-mail: email@example.com. Successful candidates will be highly motivated and have research experience in biochemistry and/or molecular biology and excellent communication skills. Some experience with extracellular vesicles and bioinformatics related to RNAseq is preferred.
Internal Number: 001
About University of California San Diego
Dr. Risbrough’s research is centered on translational mechanisms and treatments of anxiety disorders using preclinical and clinical approaches. Her primary focus is understanding mechanisms of risk and resilience to trauma disorders, particularly post-traumatic stress disorder and traumatic brain injury. She oversees both a preclinical and clinical research program. Her preclinical research program focuses on using molecular, pharmacological and genetic techniques in rodent models of trauma to identify mechanisms of enduring effects of trauma on the brain and body. Her clinical research program uses physiological, pharmacological, molecular and imaging techniques to identify biological markers of trauma risk and symptom development and to identify mechanisms of PTSD and TBI and their associated comorbidities.
The University of California, San Diego is located on the La Jolla Mesa in close proximity to San Diego Veterans Affairs Hospital, the Scripps Research Institute, the Salk Institute, and the Sanford Burnham Prebys Medical Discovery Institute Research and provides a highly stimulating, collaborative, and interactive research environment in a beautiful location.