A postdoctoral position is available in the laboratory of Dr. Miles Herkenham, NIMH, to study the role played by immune molecules and cells contributing to immune-to-brain communication relevant to mental disorders. The postdoctoral fellow will design and carry out experiments in mice to study neuroimmune components of affective disorders. Chronic social defeat stress produces depressive-like behaviors in mice and induces central and peripheral immune responses that in turn affect behavioral, anatomical, and physiological measures. Approaches include characterization of behavior and depressive or anxiety-like states, histochemical mapping of responsive genes and GFP in transgenic reporter mice, flow cytometry of immune cells in the periphery, meninges, and brain, microarray of gene expression following physiological or immunological challenge, manipulation of the peripheral innate and adaptive immune environment, assays of primary cells in culture containing isolated brain and immune cells, and pharmacological and non-pharmacological interventions in wildtype and transgenic reporter or knockout mice.
The Section on Functional Neuroanatomy is located in the Porter Neuroscience Research Center on the main NIH campus and is part of the Laboratory of Cellular and Molecular Regulation, Intramural Research Program, NIMH (Section on Functional Neuroanatomy). Candidates should send CV, contact information for three references, and a cover letter to Dr. Miles Herkenham (firstname.lastname@example.org).