The Mukamel lab at UC San Diego is recruiting a talented and dedicated postdoctoral fellow to spearhead a Human Cell Atlas/CZI funded project, investigating individual variability in human cell type transcriptomes and epigenomes. This project builds on our lab's recent work on single cell DNA methylation profiling and analysis (Lister, Mukamel et al., Science 2013; Luo et al, Science 2017). Our studies have shown that neurons have unique patterns of DNA methylation, including widespread non-CG methylation. These epigenomic marks are highly specific signatures of neural cell type and identity. As part of the broader Human Cell Atlas (HCA), we are working to map the epigenomes and transcriptomes of human brain cells. We will map variation due to age and sex, and inter-individual variability that may be related to lived experience.
Our group is a computational neuroscience and bioinformatics lab, specializing in developing and applying sophisticated computational tools to neuronal epigenomics data. We welcome applications from scientists with any background who are passionate about using computation to unlock the potential of large-scale neural datasets.