Postdoctoral position in the laboratory of Vivek Unni, MD, PhD, in the Jungers Center for Neurosciences Research at Oregon Health & Science University. This position focuses on discovering the mechanisms by which neurons die in neurodegenerative disease. The Unni Lab has recently discovered an unexpected function for the protein alpha-synuclein in DNA double-strand break repair (Schaser et al., 2019). This function may be important in the neurodegeneration associated with Lewy body formation in diseases like Parkinson's Disease and Lewy Body Dementia, and malignant transformation in cancers like melanoma. We are investigating the role/s of alpha-synuclein using a combination of approaches in mice, including in vivo multiphoton imaging via cranial windows, in cultured cells and reduced biochemical systems. The ideal postdoc candidate is an intelligent, hard-working, self-motivated person with PhD training in the biological sciences. Expertise in DNA repair biology is a significant plus. This project requires expertise in at least one of several techniques, including molecular biology, cell culture, immunohistochemistry, in vivo and in vitro fluorescence microscopy, and/or small rodent handling/surgery techniques
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About Oregon Health & Science University
OHSU's singular focus on improving health starts with Oregonians and has global impact. We are the only academic health center in Oregon, but we're also nationally distinct as a university dedicated solely to advancing health sciences. This allows us to concentrate resources on research to prevent and cure disease, on education that prepares physicians, dentists, nurses and other health professionals to succeed in an evolving health care environment, and on patient care that incorporates the latest knowledge and discoveries. Based in Portland, we have 16,000 employees, operate the top-ranked adult and children's hospitals in Oregon, and secure competitive research funding of more than $400 million a year. As a public organization, we provide community outreach and services for Oregon's most vulnerable populations.