A position for a postdoctoral fellow is open in the laboratory of Dr. Raymond Koehler in the Department of Anesthesiology and Critical Care Medicine at Johns Hopkins University. The NIH-supported research focuses on the mechanisms of neuroinflammation in experimental models of stroke and on how modifying neuroinflammation affects neuronal cell death, astrocyte and oligodendrocyte function, blood-brain barrier, neurogenesis, and brain repair. Experimental models include intracerebral hemorrhage and middle cerebral artery occlusion with neurobehavior testing and MRI. Primary cell cultures and organotypic slice cultures are also used with an emphasis on astrocyte and microglia signaling and communication. The candidate will perform in vivo and in vitro experiments, histopathology and immunostaining, optical imaging techniques, FACS sorting, RT-PCR, siRNA interventions, ELISA, Western blotting, neurobehavior testing, management of transgenic mouse colonies, statistical analysis, and writing manuscripts.
The candidate should have a doctorate degree with expertise in neuroscience, immunology, or cerebrovascular biology and at least one first-author publication in a peer-reviewed journal. The candidate is expected to present at scientific conferences and to draft manuscripts, and thus good oral and written communication skills in English are required. Prefer candidates with experience with rodent surgery and primary cell or organotypic slice cultures, histopathology, immunostaining, various types of microscopy, FACS sorting, RT-PCR, siRNA interventions, ELISA, Western blotting, neurobehavior testing, and statistical analysis.
Internal Number: Koehler002
About Johns Hopkins University
From its beginning in 1893, the Johns Hopkins University School of Medicine revolutionized the education of physicians in the practice of medicine and medical research nationally and internationally by applying unprecedented standards to medical training. It annually receives more research grants from the National Institutes of Health than any other medical school and consistently is ranked among the top medical schools in the nation. Diverse and inclusive, Johns Hopkins Medicine educates medical students, scientists, health care professionals, and the public, conducts biomedical research, and provides patient-centered medicine to prevent, diagnose, and treat human illness.