The laboratory of Brian Kraemer seeks a Postdoctoral Fellow to join a multi-disciplinary collaborative research team focused on the molecular genetics of neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, and amyotrophic lateral sclerosis. We are investigating the molecular mechanisms of aging induced protein aggregation and neurodegeneration using forward genetic approaches. This research project is supported by an NIH funded R01 grant. Dr. Kraemer is faculty at the University of Washington School of Medicine in Seattle, Washington.
A PhD in a relevant field of the biomedical science.
Experience designing and executing well controlled experiments.
Ability to work both independently and as a collaborative team member.
US citizenship or permanent resident status (green card).
Experience with genetic analysis methods in model organisms
Knowledge of neurobiology and/ or RNA binding protein function
Please reply with a cover letter and CV in PDF format.
Internal Number: 69079
About University of Washington
As an investigator at the VA Puget Sound Health Care System, Dr. Kraemer’s research explores how protein aggregation contributes to neurodegenerative diseases including Alzheimer’s disease and amyotrophic lateral sclerosis. Dr. Kraemer has developed animal models of the tau pathology seen in Alzheimer’s disease using both transgenic mice and transgenic C. elegans. Dr. Kraemer’s current work focuses on dissecting the genetic requirements for tau mediated neurodegeneration in these models. The approach taken is to use the experimental advantages of C. elegans to identify genes involved tauopathy and TDP-43 proteinopathy. The role of these newly identified genes will be explored using transgenic mouse models. As new genes are identified that participate in tau and TDP-43 neurotoxicity, potential strategies for preventing neurodegeneration can be tested with the ultimate goal of developing effective therapies for neurodegenerative disease.