A postdoctoral position is available in the Dunn laboratory in the Department of Neurological Surgery and the Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs (CHiiPs) at Washington University in St. Louis. We are seeking an intelligent, creative, and collegial post-doctoral fellow to study neoantigen discovery and targeting in glioblastoma using basic and translational approaches. We perform pre-clinical mouse modeling and human translational work towards identifying and targeting neoantigens to understand therapeutic opportunities and basic CNS immunobiology. Our group has expertise in neoantigen discovery in both preclinical and translational settings.
Research areas include cancer genome discovery, preclinical brain tumor models, and analysis of patient derived T cell and tissue samples to study immunogenicity and immunogenomics.
We are a highly collaborative group and interact closely with cancer biologists, clinicians, and computational biologists to comprehensively understand the immunobiology of glioblastoma and brain metastases.
The major focus of this position will be to perform immunologic studies using mouse glioblastoma models and human brain tumor specimens. These experiments center on neoantigen discovery and T cell responses and will include transcriptomic approaches.
Specific responsibilities include
Processing and analysis of patient-derived tissues
Carrying out cell culture and mouse studies
Performing laboratory experiments, conducting data analysis and interpreting results
Designing experiments and executing protocols
Maintaining accurate records, writing reports, and preparing and giving presentations
Contributing to the overall laboratory safety, organization and productivity
Interested candidates with relevant qualifications should email curriculum vitae including a summary of their research, list of publications, and contact information for three recent references to Megan Fenlon at Megan.Fenlon@wustl.edu.
M.D./Ph.D. or Ph.D in molecular biology, immunology or equivalent
Enthusiastic, team player, and self-motivated individual
Experience with cell culture and immunologic assays including FACS and ELISPOT
Excellent written and oral communication skills
Experience with immunology related laboratory approaches is desirable but not critical
Internal Number: 45533
About Washington University
Using immunology and genomics tools, we study how the immune response to brain tumors happens. We use established preclinical models, new preclinical models we have developed, and patient-derived tissue and cells to address what T cells recognize and how antigen is presented. These studies are complemented by clinical trial efforts. Our ultimate goal is to better understand the diseases of our patients in order to develop improved therapies.