Sr Associate Scientist - Molecular and Cellular Neuroimmunology (#R-83516)
Amgen Neuroscience is looking for a motivated biologist to be a key contributor in our efforts to develop therapies for neurodegenerative disease at Amgen's site in Cambridge, MA (Amgen Massachusetts-AMA). As the field of neuroimmunology holds great potential for neurodegenerative disease treatments, the candidate will be charged with the design and generation of assays to drive decisions in the drug discovery process. Additionally, the role will also include the study of cellular and biochemical processes behind the genetic insights arising from our global collaborations. This position is for the dedicated experimentalist who seeks to work in a multidisciplinary team as part of our pre-clinical research. Core areas of focus will be translating genetics and human biology observations into both in vitro and in vivo systems to understand modifiers of neurodegenerative pathology.
Overall, the position is ideal for someone seeking to become a technical leader and a critical resource within Amgen Neuroscience. A core aim will be discovering new biological insight to enable drug discovery programs from target validation through clinical development.
Planning and execution of cellular and biochemical in vitro assays to understand fundamental neurological and immunological processes. Responsible for delivering reproducible and well-controlled datasets according to project timelines
Generation of in vitro models and assays for drug discovery and target validation to demonstrate assay robustness
Perform in vitro pharmacology in automated and semi-automated assay workstreams
Assist team members in collaborative in vivo pharmacology with pre-clinical neurodegenerative disease models
Contribute innovation, ideas, and literature insights to support the development of novel approaches to study immune processes in the brain
Doctorate degree or Doctorate degree completed by December 2019
Master's degree and 3 years of scientific experience
Bachelor's degree and 5 years of scientific experience
Expertise in biochemical and molecular biological techniques, including qRT-PCR, DNA/RNA/Protein visualization, western blotting, protein immuno-precipitations, ELISA, RNAi, and molecular cloning
Demonstrated application of mammalian cell culture and associated techniques with an emphasis on cell line development
Previous research focused on the immune system and/or immunoassays
Experience with fluorescence activated cell sorting (FACS) and analysis
Ability to utilize viral-based gene transduction systems
Strong proficiency in written and spoken English with the ability to convey ideas and information clearly
Proficient with statistics and scientific data analysis software (e.g., Graphpad Prism, SigmaPlot)
Pharmaceutical industry experience is desirable
Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.
Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.
Amgen's outstanding compensation package features comprehensive benefits. To learn more about this opportunity and to apply, please visit us online at http://careers.amgen.com/ and search job #R-83516.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.