The Lab for Circuit & Behavioral Physiology at RIKEN CBS (https://cbs.riken.jp/en/faculty/t.mchugh/) is seeking multiple postdoctoral researchers for a new series of projects. We have recently combined our expertise in physiology with the emerging technology of memory engram labeling, based on the combination of immediate early gene expression and optogenetics, to functionally tag, identify & manipulate neurons involved in the encoding of a specific memory. We seek creative scientists to build on this work, extending it to other regions of the hippocampus and cortex and addressing the interactions of neurons across brain regions during memory consolidation and recall. Further, the identification of a general signature of neurons engaged by memory will allow us to train algorithms with data from the high density recording to permit the identification of engram neurons based on physiology alone, without the need for optogenetic identification. These projects will also be part of an ongoing collaboration with the Jones lab at the University of Bristol, UK.
We seek a highly motivated researchers with an interest in learning and memory and physiology.
Applicants should have a PhD in neuroscience or a related field with a background including electrophysiological experience, optogenetic experience, analysis of neural spike train data, and knowledge of the neurobiology of memory. Candidates with direct experience of multi-channel recordings from the CNS, software programming and/or electrical engineering expertise for both data analysis and device control and experience of behavioral training of mice will be most competitive.
Candidates for the computational position will take the lead in generating analytical and computational approaches to capture key features of electrophysiological data recorded in mouse hippocampus and cortex. This work will be done in close collaboration with experimentalists conducting high density neural recordings combined with optogenetic methods to jointly design new paradigms based on observations and predictions spurring from the theoretical work.
Internal Number: W19088, W19089, W19090
About RIKEN Center for Brain Science
Located just outside of Tokyo, RIKEN CBS is Japan’s premier research center for brain science. The Center takes a multi-disciplinary approach involving medicine, biology, chemistry, engineering, mathematical sciences, and psychology, to advance basic research on the functions of the brain and the mind—from the levels of single-cells and whole bodies all the way to societal systems—and develop innovative technologies in the process.