A postdoctoral associate position is available in the Jacob lab (Pharmacology & Chemical Biology Department, University of Pittsburgh School of Medicine). We are seeking a postdoc to contribute to an ongoing NIH funded project investigating molecular mechanisms underlying tolerance to benzodiazepines (BZ), a key clinical drug class. These drugs positively modulate GABA type A receptors and are used as front-line treatments for anxiety, insomnia, schizophrenia and epilepsy. In addition, we are testing mechanism-based treatment paradigms to reduce or reverse key neuroadaptations occurring with BZ tolerance.
The Jacob lab’s broad goal is to uncover molecular signaling mechanisms and understand the impact of dynamically regulated GABAA receptor (GABAAR) surface levels and distribution in normal development, pathological conditions, and during drug therapy. The lab uses in vitro and in vivo models, applying high-resolution live imaging, pharmacological, proteomic, behavioral, biochemical, and electrophysiological approaches. See recent publications, see https://www.ncbi.nlm.nih.gov/myncbi/1x7rldM4jnwkG/bibliography/public/
The Jacob lab is a member of the internationally recognized School of Medicine’s Department of Pharmacology & Chemical Biology and the Center for Neuroscience at University of Pittsburgh and provides a highly collaborative scientific environment. In addition Pittsburgh is a desirable and affordable city with a moderate climate and many cultural and recreational opportunities. https://www.nytimes.com/2015/07/19/travel/what-to-do-in-36-hours-in-pittsburgh.html
Candidates must hold a Ph.D. and have a strong background in biochemistry, pharmacology, or neurobiology. Candidates should also have a minimum of one first author paper published or accepted in a well-recognized peer-reviewed journal. Preference will be given to individuals with experience in molecular neurobiology, biochemistry or electrophysiology.
Strong self-motivation, independence and good communication skills!
Candidates should send a letter of interest (including a brief description of research interests and career goals), CV and contact information for three references to Dr. Tija C. Jacob, Ph.D. (firstname.lastname@example.org). The University of Pittsburgh is an Equal Opportunity/Affirmative Action Employer.