The Translational Neuroscience Laboratory (PI: Sabina Berretta) and the Translational Molecular Genomics Laboratory (PI: Torsten Klengel) at McLean Hospital seek a postdoctoral fellow with a strong background in molecular neuroscience, glial biology, post-mortem brain research or related areas as well as excellent organization skills and attention to detail. We expect that a successful candidate will strongly interact with a multidisciplinary team of scientists investigating the molecular mechanisms of psychiatric disorders in the mammalian brain to gain further understanding of debilitating human psychiatric disorders such as Schizophrenia, Bipolar Disorder, Depression and PTSD. This role will include both molecular/wet lab and data driven approaches. Applicants should have a strong interest in preclinical as well as translational neuroscience. Prior experience with high-throughput data analysis is an advantage. This is a two-year position with a potential for non-competitive renewal for later years, contingent upon performance and funding.
The Berretta Lab focuses on the neurobiological underpinning of psychiatric symptoms. Two of the main areas of research are the interactions of extracellular matrix, neurons and glia in the pathophysiology of psychiatric symptoms and the role neural circuits involved in stress/anxiety and reward/pleasure. Dr. Berretta is also the Director of the Harvard Brain Tissue Resource Center. Her lab utilizes human postmortem tissue, animal models and cell culture in combination with a diverse set of methods for detection of protein and gene expression.
The newly established Klengel Lab has a highly translational approach studying psychiatric disorders in animal models and humans using genomic technologies, in-vitro models and molecular assays. Both labs maintain a highly interactive collaboration sharing expertise and ideas.
Candidate will work on projects interfacing psychiatric disorders (schizophrenia, bipolar disorder), aging and aging-related disorders, extracellular matrix biology and high-throughput omics and machine learning approaches.
The successful candidate will be proposed for academic appointment as a Research Fellow in the Department of Psychiatry at Harvard Medical School.
Process and analyze post-mortem tissue samples (including sectioning with a microtome/cryostat, and immunohistochemistry, RNAscope, quantitative light and confocal microscopy); process and analyze clinical data
Perform and analyze DNA, RNA and protein experiments (including western blots, PCR and qPCR)
Perform and analyze RNAseq experiments
Prepare scientific manuscripts and present data during professional meetings
Assist PI in preparing grant applications
Train research assistants and junior investigators.
D. in Neuroscience or a related field (or equivalent) is required.
The fellow will cover a wide range of responsibilities in line with the translational approach of the lab.
Please include the names & contact details for three references in your application.
There are many opportunities for education and growth in our multidisciplinary, collaborative research environment at McLean Hospital that brings together a diverse group of neurobiologists, clinicians, psychologists and statisticians. Please see https://www.mcleanhospital.org/research
McLean Hospital, an affiliate of Harvard Medical School, is an Equal Opportunity Employer. It is the policy of McLean Hospital to affirmatively provide equal opportunity to all qualified applicants for employment and existing employees without regard to their race, religion, color, national origin, sex, age, ancestry, protected veteran status, disability, sexual orientation, gender orientation or any other basis that would be in violation of any applicable law or regulation. McLean Hospital does conduct pre-employment drug screening, and any offer of employment is contingent upon satisfactory results of the screening.