Dr. John H. Morrison, Professor of Neurology and Director of the California National Primate Research Center (CNPRC), is seeking to hire 1-3 postdoctoral fellows, 100% time for the duration of two years with the possibility of extension. The postdoctoral fellows will be expected to participate in our research program investigating the synaptic and cellular basis of cognitive decline in rhesus monkeys. In this research program, we have identified several reflections of synaptic health that deteriorate with aging, leading to cognitive decline. A key question being pursued is whether or not such synaptic alterations can transition to the neurodegenerative events seen in Alzheimer’s Disease (AD) under certain circumstances. In order to pursue this question in the Rhesus monkey model, we have developed two monkey models of early AD, one based on the synaptic toxicity of Ab oligomers, and one based on the capacity for phospho-tau aggregates to initiate neurodegeneration. Both models show great promise and are currently being pursued in the laboratory. We are also pursuing other models of cognitive decline that have a high degree of translational impact on human health. While molecular approaches are being pursued, most of the lab’s work involves high resolution quantitative microscopy to reveal both synaptic and cellular alterations that are predictive of cognitive decline. Behavioral and in vivo imaging approaches are also employed. The CNPRC, Department of Neurology, and Center for Neuroscience converge to provide an outstanding training opportunity in Dr. Morrison’s laboratory for neuroscientists at multiple stages of development.
Salary: Commensurate with experience, following NIH guidelines.
Qualifications: Applicant must have a Ph.D. in cellular or systems neuroscience, cell biology, biochemistry, molecular biology or a related scientific field. It is preferable that the successful applicant has experience with either 1) quantitative microscopy, or 2) biochemical analyses of brain tissue.
The applicant must have excellent communication skills and have the motivation to pursue and drive projects independently.
Candidates should be willing to apply for independent funding.
Internal Number: JPF02881
About UC Davis-Primate Center
The CNPRC is an Organized Research Unit of the University of California, Davis and part of the National Primate Research Centers Program. The CNPRC mission is to improve human health and quality of life through support of exceptional nonhuman primate research programs. The CNPRC is one of seven such centers supported by the National Institutes of Health. The National Primate Research Centers are a unique resource for investigators studying human health and disease, offering the opportunity to assess the causes of disease, and new treatment methods in nonhuman primate models that closely recapitulate humans. Research performed at the CNPRC and other National Primate Research Centers provides necessary information before proceeding to clinical trials in humans, leading to new drugs, therapies and surgical procedures that benefit human health and quality of life.