We are looking for intelligent, pleasant, highly motivated Postdoctoral Fellows/Research Assistant Professors who have a strong training background in in vitro electrophysiology and interests in epilepsy and cortical development.
We are using a variety of tools to understand how somatic mutations in cortical progenitors lead to epilepsy. Established research platforms in the lab include CRISPR/CAS9 in utero electroporation, cell-type specific transgenics, rodent MRI, in vivo electrophysiology including local field potentials and single unit recordings as well as human intracranial EEG data and pathology. Promising therapeutic targets are also tested in our focal cortical epilepsy and glioblastoma animals that precisely recapitulate human diseases at genetic, cellular and functional levels. State-of-the-art in vitro electrophysiology will be used to ask 1. whether and how mutant pyramidal cells non-cell autonomously impair interneuron development and function; 2. how mutant pyramidal neurons or interneurons contribute to epileptogenesis and cortical hyperexcitability; 3. Whether and how cortical interneuron transplantation suppress focal cortical seizures.
We are collaborating with Geoffrey Murphy, Vikram Shakkottai, Brendon Watson, Jack Parent, Bill Stacey and Lori Isom whose labs are located at the same floor or adjacent buildings. They are smart and cool people, and it is fun to work with them. As such, collaborative applicants with good communication skills and are highly valued.
Dr. Yu Wang is an epileptologist and neuroscientist and aims to address highly clinically-relevant questions with hope to translate scientific discoveries and therapeutic development into clinical trials/applications. The projects are funded by a NIH K08 and will be continuously funded by a R01.
For more information: https://medicine.umich.edu/dept/neurology/yu-wang-md-phd
1. Interested and motivated in running an Ephys laboratory and setting up new experiment paradigms
2. Good communication skills, independent and fun to work with.
Internal Number: 062019
About University of Michigan Comprehensive Epilepsy Program
The University of Michigan and the Taubman Medical Research Institute provide an outstanding and extremely collaborative biomedical research environment. The Taubman Medical Research Institute is in the heart of University of Michigan medical campus and basic science campus. It has a large group of scientists with expertise in genetics, stem cell, development, immunology and electrophysiology. The multi-disciplinary and interactive environment encourages collaborations and there is an extraordinary amount of ongoing projects using mouse models and stem cells to study human diseases.