Chronic pain is a highly prevalent neurological condition, affecting 30% of the US population. The recent epidemic of opioid related deaths has drawn attention to the lack of effective non-addictive pain treatments available. The goals of this project are to determine the molecular and cellular organization of mouse and primate (human and non-human) spinal cord dorsal horns and to use this information to investigate the functional neural circuitry underlying chronic pain.
Our laboratory has been investigating the neural circuitry for chronic pain in mice (See Moehring et al, Neuron, 2018, Peirs and Seal, Science, 2016 and Peirs et al, Neuron, 2015) and are now extending these studies to primates with the eventual goal of developing a treatment that targets chronic pain in humans.
The successful candidate will design and perform experiments to identify the neural circuitry for chronic pain using cutting-edge approaches such as single cell or nucleus sequencing, ATAC-seq, barcoded library screens, viral injection of designer receptors, behavior and histology.
The training experience of the successful candidate will be further enhanced by being a member of the Pittsburgh Center for Pain Research (see http://www.paincenter.pitt.edu/), which holds weekly journal club, bimonthly research in progress presentations, monthly seminar series and courses on pain.
The successful candidate will also have the opportunity to participate in national and international meetings, apply for grants, write manuscripts and reviews, as well as interact with other laboratories at the University of Pittsburgh and Carnegie Mellon University and also pain clinicians at the University of Pittsburgh Medical Center.
ABOUT THE EMPLOYER
The successful candidate will become part of a large, vibrant, multidisciplinary, and internationally recognized neuroscience community at the University of Pittsburgh. The laboratory is located in the Department of Neurobiology in the School of Medicine. Pittsburgh offers numerous cultural and sports activities as well as an affordable lifestyle for young professionals. Consistently rated Most Livable City in the US by the Economist and Forbes Magazine.
MD or PhD in neuroscience, physiology, molecular biology or related disciplines. Candidates with experience in molecular techniques are especially encouraged to apply.
Creative thinking skills, command of the neuroscience literature, affinity for performing experimental animal research and ability to work collaboratively with excellent communication skills are desired.
Please email your CV and three references to Dr. Rebecca Seal email@example.com
Internal Number: 061719
About University of Pittsburgh
The University of Pittsburgh is currently ranked third in NIH funding and the city of Pittsburgh is ranked second most livable in America, according to The Global Livability Index 2018.
The University of Pittsburgh is an Affirmative Action/Equal Opportunity Employer and values equality of opportunity, human dignity and diversity. EEO/AA/M/F/Vets/Disabled