Chronic pain is a highly prevalent neurological condition, affecting 30% of the US population. The recent epidemic of opioid related deaths has drawn attention to the lack of effective non-addictive pain treatments available. The goals of this project are to determine the neural basis of spontaneous pain (the most commonly experienced type of pain) and tactile allodynia (where light touch becomes painful with injury) and to use the information to identify novel treatment strategies.
Our laboratory has been working out the circuitry for tactile allodynia and will extend the investigation to include spontaneous pain. We have concentrated largely on the spinal cord dorsal horn and are now expanding our efforts to include connections to primary sensory neurons and the brain. (See Moehring et al, Neuron, 2018, Peirs and Seal, Science, 2016 and Peirs et al, Neuron, 2015)
The successful candidate will design and perform experiments to identify the neural circuitry for tactile allodynia and spontaneous pain using cutting-edge approaches such as patch clamp electrophysiology with channelrhodopsin, in vivo calcium imaging, viral tracing, and designer receptors.
The training experience of the successful candidate will be further enhanced by being a member of the Pittsburgh Center for Pain Research (see http://www.paincenter.pitt.edu/), which holds weekly journal club, bimonthly research in progress presentations, monthly seminar series and courses on pain.
The trainee will also have the opportunity to participate in national and international meetings, apply for grants, write manuscripts and reviews, as well as interact with other laboratories at the University of Pittsburgh and Carnegie Mellon University and also pain clinicians at the University of Pittsburgh Medical Center.
ABOUT THE EMPLOYER
The successful candidate will become part of a large, vibrant, multidisciplinary, and internationally recognized neuroscience community at the University of Pittsburgh. The laboratory is located in the Department of Neurobiology in the School of Medicine. Pittsburgh offers numerous cultural and sports activities as well as an affordable lifestyle for young professionals. Consistently rated Most Livable City in the US by the Economist and Forbes Magazine.
DESIRED SKILLS AND EXPERIENCE
MD or PhD in neuroscience or related field within the past 0-2 years, with a track record of productivity and innovation. Experience with patch clamp electrophysiology in tissue slices preferred.
Creative thinking skills, command of the neuroscience literature, affinity for performing experimental animal research and ability to work collaboratively with excellent communication skills are desired.
Please email your CV and three references to Dr. Rebecca Seal firstname.lastname@example.org
Internal Number: 061619
About University of Pittsburgh
The University of Pittsburgh is currently ranked third in NIH funding and the city of Pittsburgh is ranked second most livable in America, according to The Global Livability Index 2018.
The University of Pittsburgh is an Affirmative Action/Equal Opportunity Employer and values equality of opportunity, human dignity and diversity. EEO/AA/M/F/Vets/Disabled