We seek a highly-motivated individual who enjoys the opportunity to collaborate with clinicians yet pursue his or her own ideas in a supportive environment. We seek to understand and ultimately modulate molecular, cellular, and circuit mechanisms underlying the development and persistence of temporal lobe epilepsy in humans.
Presently we have active projects in:
Two-photon imaging of BDNF-TrkB signaling in single dendritic spines of CA1 pyramidal neurons undergoing synaptic plasticity
Targeted inhibition of TrkB for prevention of epileptogenesis
Synaptic plasticity mechanisms underlying LTP and LTD of mossy fiber-CA3 synapses
The focus of this position is on cellular physiology and invivo imaging of dendritic spines in hippocampal circuits undergoing epileptogenesis with possible translation into application in humans. The strong interdisciplinary and collaborative environment at Duke is ideal for our translational research efforts.
An earned Ph.D. and/or M.D. and previous experience in cellular electrophysiology are required. Previous experience with cellular imaging both in vitro and in vivo is preferred but not necessary.
Additional Salary Information: NIH guidelines tailored to years of postdoctoral experience
Internal Number: 007
About Duke University
James McNamara, M.D. is a professor of neurobiology at Duke University.