A NIH-funded postdoctoral position is available in the laboratory of Dr. Scott Rawls in the Department of Pharmacology and Center for Substance Abuse Research (CSAR) at Temple University (Lewis Katz School of Medicine) in Philadelphia. One major project is aimed at determining how neuroinflammatory markers (e.g. cytokine, chemokine and purinergic systems) in brain reward substrates are impacted by psychostimulant (cocaine and ‘bath salt’ cathinone MDPV) and opioid drug intake. Pharmacological studies will investigate how chemokine and puringergic receptor antagonism influence psychostimulant/opioid reward, reinforcement and relapse. A second project is directed toward studying analgesic, neuroprotective and potentially addictive effects of the active constituents of kratom (mitragynine and 7-hydroxymitragynine) and identifying underlying opioid, adrenergic and serotonergic mechanisms.
We utilize a combination of behavioral (self-administration, conditioned place preference, ICSS, forced swim, elevated plus maze), neurochemical (in vivo microdialysis/HPLC), cellular (gene/protein expression, immunohistochemistry, binding), and pain (acute, neuropathic) assays. We also use contemporary drug discovery approaches through collaborations with medicinal chemists.
The successful candidate will join a highly-interactive neuroscience community and work as part of a team that includes members of other laboratories in CSAR and the Department of Pathology and Laboratory Medicine. Eligible candidates have the possibility of being appointed to a NIH-funded T32 training grant.
A recent Ph.D. degree in neuroscience, pharmacology, or a related discipline is preferred. Submit a curriculum vitae and contact information for 3 referees to Scott Rawls, Ph.D., firstname.lastname@example.org. Salary will be commensurate with qualifications, laboratory experience, and institutional guidelines.
Internal Number: 10
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