iPSC-derived retinal photoreceptors to restore vision
Many diseases of the retina causing blindness may potentially be treated by cell transplantation. Several significant barriers currently limit advancing stem cell therapies to translation, such as low levels of engraftment, limited orientation of donor cells within the retina, and deleterious host-donor cell interactions. We are seeking post-doctoral researchers to develop iPSCs and organoid retinal development for transplantation into large animal models of human inherited retinal degeneration. This is a new multi-institutional program to advance translational approaches to restoration of retinal function. (see https://nei.nih.gov/content/five-research-teams-will-develop-new-models-eye-disease-research).
Disseminated neural stem cell engraftment
The project will study NSCs derived from reprogrammed human pluripotent stem cells. We are investigating factors that affect post-injection survival and migration, utilizing tissue culture and genetic manipulations, to treat global brain disease lesions. Experience with iPSCs a plus.
The successful candidate will have latitude to develop his/her own ideas within the scope of the project. The studies are supported by a NIH grant and the fellow will have latitude to develop his/her own ideas within the scope of the project. Please send a CV, description of career goals and interests, and names of 3 references to: Dr. John H. Wolfe, Research Institute of Children's Hospital of Philadelphia, email@example.com.
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