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Functional Neurosurgery Bioengineer
University of Denver
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Functional Neurosurgery Bioengineer

University of Denver

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Details
Posted:
January 23, 2019
Location:
Denver, Colorado
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Salary:
Type:
Full Time - Experienced
Discipline:
Academic / Research
Required Education:
Doctorate

The Functional Neurosurgery Bioengineer is a unique joint position based at the University of Denver Knoebel Institute for Healthy Aging with primary clinical  responsibilities at St Joseph’s Hospital and Kaiser Permanente in central Denver.

The Functional Neurosurgery Bioengineer (FNB) has the primary clinical responsibility  for the development and implementation of the technology support for the neurosurgical  interventions of the Functional Neurosurgery Service. That support includes the services  of the: 

  1. Deep Brain Stimulation (DBS) and Movement Disorders Program,   
  2. Epilepsy Monitoring Unit (EMU) and Surgical Epilepsy Program,   
  3. Neuro­Oncology Functional Cortical Mapping Program,   
  4. Functional MRI neuroimaging program. 

The Functional Neurosurgery Bioengineer acts as a member of the intraoperative  professional team in mapping and assisting placement in the selection of the radiographic  location of Deep­Brain Stimulation leads for movement disorders. The FNB plans  MRI­based targeting and trajectories with the neurosurgeon, performs intraoperative  radiographic and neurophysiological analysis to determine intracranial locations of  mapping and stimulation electrode. The FNB will develop 3D rendering of electrode  locations within the brain to allow for appropriate interpretation of Deep Brain  Stimulation side effects for DBS programming.    

The FNB acts as a member of the surgical epilepsy program in radiographic and  stereotactic planning for placement of epilepsy depth electrodes (stereo EEG), subdural  grid and strip electrodes, and depth electrodes for epilepsy neuromodulation (Responsive  Neurostimulation, RNS). The FNB also supports the epileptologist in bedside functional  mapping with electrical stimulation in the EMU to identify eloquent areas of brain  function such as language and motor cortex. The FNB will develop 3D rendering of  electrode locations on and within the brain to allow for appropriate interpretation of  surgically invasive EEG recording. 

The FNB acts as a member of the surgical team for neuro­oncology program in functional  cortical mapping. The FNB would perform pre­surgical patient education, and manage the operative setup and assist in intraoperative awake electrical stimulation mapping,  coordinating with epileptologist, neurosurgeon, and neuro­monitoring technicians. They  would have the primary role for operating the cortical stimulation system.   

The FNB will act as an integral member of the team for functional MRI in coordination  with the neuro­radiologist and MRI technicians. The FNB will perform patient education  for functional MRI performance tasks. The FNB will ensure the technical accuracy of the  functional MRI product. The FNB will perform all post­processing to develop maps of  cortical function. The FNB will interface with the intraoperative neuronavigation systems  to bring these functional MRI images into the operating room navigation systems.     

The FNB will act as a member of the safety team for MRI­safe imaging of  neuromodulation implant devices, including Deep Brain Stimulation, Responsive  Neurostimulation.   

The FNB will also work with the MRI department technicians to ensure stereotactic  accuracy of the MRI system, assisting with conducting stereotactic calibration to ensure  MRI system is accurate for neurosurgical procedures.

For more information please contact: adam.hebb@aoh.md

 

MAJOR RESPONSIBILITIES:    The Functional Neurosurgery Bioengineer has the primary responsibility for overall  technology development, technical neurophysiological support and management of the  Functional Neurosurgery Service that includes the DBS Movement Disorders Program,  Surgical Epilepsy program, Neuro­oncology functional cortical mapping program, and  Functional MRI program.    

Clinical Neurosurgery Roles: 

DBS Movement Disorders Program 

  1. Clinical Neurophysiology role during DBS surgeries and peri­operative period: 
    1. Analysis of intraoperative neurophysiological data.
    2. Perform technical aspects of neural signal processing such as intraoperative microelectrode recording (multi­unit activity), spike sorting  and frequency band analysis with respect to behavior and somatosensory  input.
    3. Develop computer algorithms for neural signal processing to help guide  accurate placement of Epilepsy and DBS electrodes.
    4. Functional analysis of implanted stimulation and recording systems such  as measurement of lead impedance and physician directed adjustments of  system settings.
    5. Conduct standardized clinical tests of disease states such as United  Parkinson's Disease Rating Scale (UPDRS), Fahn–Tolosa–Marin Tremor  Rating Scale, Toronto Western Spasmodic Torticollis Rating Scale  (TWSTRS).
  2. Neuro­imaging role during DBS surgeries and peri­operative period:
    1. Perform technical aspects of stereotactic planning/targeting for electrode  placement.
    2. Assist with development of MRI protocols? oversee acquisition of  specialized MRI protocols.
    3. 3D localization of stimulation and recording electrode positions for Deep  Brain Stimulation. 

  Surgical Epilepsy program 

  1. Clinical neurophysiology role
    1. Perform technical aspects of neural signal processing in Epilepsy surgery  including frequency band analysis.
    2. Functional analysis of implanted stimulation and recording systems such  as measurement of lead impedance and physician directed adjustments of  system settings
    3. Bedside electrical stimulation and frequency band mapping of cortical  function via implanted subdural electrode arrays and depth electrodes.
    4. Perform and assist in technical aspects of designing seizure detection  algorithms for chronic implanted seizure neurostimulation and recording  systems.
    5. Training of clinical nursing and EEG technician staff where necessary 
  2. Neuro­imaging role
    1. Perform technical aspects of stereotactic planning/targeting in Epilepsy  surgery.
    2. Assist with MRI protocols for Epilepsy? oversee acquisition of specialized  MRI protocols.
    3. 3D localization of stimulation and recording electrode positions for  Epilepsy.
    4. Customized visualization of stereotactic position of cortical and  subcortical recording electrodes for Epilepsy.
    5. Support future technical advancements in Epilepsy such as robotic stereo  EEG surgery.
    6. Assist with intraoperative neuronavigation, including Epilepsy surgical  resections.
    7. Volumetric analysis of brain structures and lesions such as brain tumors  and hippocampus.   

Neuro­oncology functional cortical mapping program 

  1. Clinical neurophysiology role
    1. Participation in Functional Cortical and Subcortical Mapping for eloquent  brain function. Includes support of programs for intraoperative electrical  stimulation mapping and frequency band analysis during functional tasks  to identify critical regions during resection surgery.
    2. Patient education for awake craniotomy functional electrical stimulation  mapping.
    3. Provide assistance with intraoperative functional Electrical Stimulation  Mapping (ESM) for identification of cortical brain regions of language  and motor.
  2. Neuro­imaging role
    1. Assist with MRI protocols for Neuro­Oncology? oversee acquisition of  specialized MRI protocols.
    2. Assist with intraoperative neuronavigation, including Neuro­Oncology  surgical resections. 
    3. Volumetric analysis of brain structures and lesions such as brain tumors.   

Functional MRI program 

  1. Patient education for participating in functional MRI paradigms.
  2. Assist with MRI protocols for Epilepsy, and Neuro­Oncology? oversee acquisition  of specialized MRI protocols.
  3. Transfer of images to stereotactic planning computer for surgical planning for  Epilepsy, and Neuro­Oncology. 
  4. Image post­processing for visualization of eloquent cortical function and critical  white matter tracts? elucidation of relationships of tumor lesions and epileptic  seizure onset zones to functional cortical brain regions and subcortical white  matter tracts such as language, motor, vision.
  5. Develop and administer behavioral testing paradigms for functional MRI to  elucidate language and motor function.   

Administration roles: 

  1. Assist in administrative roles of measuring and recording program outcomes and  volumes, with preparation of necessary print and web materials for clinical  program promotion for hospital, physician group, and health care plan levels (i.e.  Annual Report). 
  2. Assist in grant, IRB and regulatory applications and administration for clinical  research programs, and clinical outcome programs.   

Education roles (Staff, Patient and family): 

  1. Patient education for participation in awake craniotomy electrical stimulation  mapping surgery, and in functional MRI paradigms.
  2. Staff education related to the area of Functional Neurosurgery.
  3. Participates in outreach activities to promote the FNS Program. 
  4. Support the care of each patient with regards to the equipment, electronics and  technology in the Functional Neurosurgery Program.   

Research roles:  

  1. There is opportunity to participate in a multi­disciplinary research group with the  University of Denver Departments of Engineering and Knoebel Institute for  Healthy Aging.   

III: EDUCATION/LICENSURE/CERTIFICATION: 

  1. Required
    1. PhD degree in neuroscience, computational neurobiology, bioengineering,  or related field.   
    2. Strong computational background with computer programming  proficiency (Python and MATLAB required).
    3. Team spirit and self motivation are required. Good communication skills  are expected. 
  2. Preferred
    1. Experience in functional MRI acquisition and post­processing.
    2. Experience in neurophysiology, including analysis of real data such as  microelectrode recording, analysis of spike and field potential data. 

Internal Number: 0
About University of Denver
Located where the Great Plains meet the Rocky Mountains, we embody the spirit of exploration and discovery that defines our region and our history. The University of Denver is a private institution built on exploration through research and collaboration among educators, students, and local and global communities. With nationally recognized academic programs, a history of widespread influence, a forward-looking vision for a 21st century education and a deep commitment to promoting inclusion, we open a world of opportunity to students and empower Pioneers to make a difference around the world.
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