Through genetic studies we identify gene candidates capable of modifying the onset and progression of symptoms in individuals predetermined to suffer from Alzheimer’s disease and related dementias. We test the ability of these gene mutations to modify molecular and cellular changes associated with Alzheimer’s disease in vitro and in vivo.
The fellow will be mentored by Dr. Joseph F. Arboleda-Velasquez in close collaboration with Dr. Diego Sepulveda-Falla from the University Medical Center Hamburg – Eppendorf, Department of Neuropathology in Germany; and Dr. Yakeel Quiroz and others in the Massachusetts Alzheimer’s Disease Research Center community of the Massachusetts General Hospital.
The fellow will have access to two extraordinarily rich preclinical hereditary dementia groups, 1) the Colombian kindred with Presenilin 1 E280A (Glu280Ala) mutation, estimated to have 1,500 mutation carriers; 2) samples and clinical data from individuals with inherited forms of vascular dementia including CADASIL; and, 3) new in vivo models for familial AD and hereditary cerebrovascular disease.
The position is open immediately and applications will be accepted until the position is filled. A CV, letter of interest outlining experience and research goals, and contact information of three references should be sent to Joseph F. Arboleda-Velasquez.
The position is full-time with benefits. Salary will be commensurate with experience. The Schepens Eye Research Institute of Mass Eye and Ear is an Equal Opportunity/Affirmative Action Employer.
Applicants should have a PhD or MD/PhD in molecular/cellular biology, genetics, neuroscience, or a related discipline, and should have a demonstrated record of experience working with in vitro and in vivo models and excellent scientific writing skills as well as excellent interpersonal skills.
Internal Number: 2
About Schepens Eye Research Institute/Massachusetts General Hospital/Harvard Medical School
I am extremely committed to teaching and mentoring the next generation of scientists. Serving as a mentor to research associates and assistants, graduate and medical students, and postdoctoral fellows is extremely rewarding to me, and has helped me substantially in the establishment of my independent laboratory and career at Harvard. As proof of my commitment, I have already directly trained more than twenty individuals with diverse backgrounds and career goals. In addition, I have taken on leadership roles at Harvard Medical School as the Faculty Director of the Paths program to assist graduate students in the process of enriching their curriculum in ways that prepare them for their professional careers in academia or outside. In addition, for over two years, I have served as the Class Mentor for the Society of Neuroscience Scholars and Associates Program to mentor a diverse community of trainees including graduate students and postdoctoral fellows using online tools and live chats. More recently and thanks to a nomination effort by my former trainees I was awarded the “Young Mentor” award from Harvard Medical School.
With my background in both clinical medicine and basic scie...nce research, I have gained substantial expertise in molecular, genetic, and biochemical studies relevant to human disease with an emphasis in vascular biology. My work both in the clinic and at the bench has given me substantial experience in translational and collaborative research that uses insights from both human and animal studies to better understand the pathobiology of human conditions.