The National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH) is seeking an outstanding post-doctoral candidate to serve in the Cellular and Developmental Neurobiology Section (CDNS) within the Division of Intramural Research. More detailed information about the NINDS Division of Intramural Research may be found at: https://neuroscience.nih.gov/ninds/Home.aspx.
Neurodevelopment Description: Work encompasses Cell lineage, Neuronal Migration, Axonal Targeting and Craniofacial development. Projects focus on differentiation and migration of GnRH cells and olfactory axon outgrowth during development of the craniofacial region. Prenatally, GnRH neurons originate in the nasal region and migrate on olfactory axons into the brain. Current projects examine: 1) lineage of the GnRH cells, 2) intracellular signaling that controls cell movement and corresponding changes in cytoskeletal elements, 3) combinatorial influence of guidance factors involved in migration of these cells into the forebrain; mechanisms common to neuronal migration as well as mechanisms specific to the GnRH system and 4) development of the craniofacial region. Candidates with experience in mouse development and imaging techniques preferred but not mandatory.
Mechanisms underlying Neuronal Activity Description: Projects focus on the mechanisms underlying neuronal activity using GnRH neurons as the model system. In vivo, GnRH neurons, spread throughout the forebrain, release GnRH in a pulsatile fashion to control reproduction. In explants, primary GnRH neurons continue to release in a pulsatile fashion and show synchronized calcium oscillations. Projects utilize the GnRH system to study molecular and cellular properties of neuronal activity (individual cells and neuronal population dynamics) at different developmental, metabolic and/or reproductive states. Candidates with experience in calcium imaging or electrophysiology and mouse anatomy preferred but not mandatory.
The laboratory in which the candidate will work utilizes multidisciplinary approaches such as, cre/lox mice, immunocytochemistry, video microscopy, calcium imaging, electrophysiology in situ histochemistry, single-cell PCR, and subtractive cDNA screening. Salary will be commensurate with experience.
The successful candidate must have an Ph.D., M.D. or D.O. degree or equivalent, and relevant training in Neurobiology, Neuroendocrinology, Molecular biology, or Developmental biology and less than 5 years experience from degree award date.
Additional Salary Information: dependent on experience