Epigenomic Mechanisms of Memory Disruption by Early-life Seizures
A postdoctoral position is offered in a vibrant Neuroscience laboratory to probe the transcriptional and epigenetic mechanisms initiated by early-life seizures that differentially program newborn and mature hippocampal dentate gyrus granule cells and pyramidal neurons. These changes cause significant disruption of hippocampus-dependent memory processes associated with epilepsy, with major clinical importance.
The NIH-funded project will employ innovative methodologies to examine, at single-cell resolution, the role of specific transcription factors in functional and structural hippocampal derangements that promote memory problems. Single-cell RNA-seq, as well as ChIP-seq, and interventional approaches will be employed. Additional methods used in the lab include DREADD technology, live 2-photon imaging, as well as DTI imaging and behavioral testing.
(See: Patterson et al., J Neuroscie, 2017; McClelland et al., eLife 2014; Singh-Taylor et al., Molec Psych 2018; Bolton et al., Biol Psych 2018; Dube et al., Trends Neuroscie 2007)
The laboratory is located on the UC Irvine campus, a rich, diverse community of MOlecular and Neuroscience research within Southern California.
Candidates should have a recent PhD degree and experience in Molecular Biology and must be highly motivated. Experience in Bioinformatics and Neuroscience is desirable.
Please send a CV, a brief statement of research accomplishments and interests, and a list of references to email@example.com.
Internal Number: 11142018
About University of California - Irvine
In 1965, the University of California, Irvine was founded with a mission to catalyze the community and enhance lives through rigorous academics, cutting-edge research, and dedicated public service. Today, we draw on the unyielding spirit of our pioneering faculty, staff, and students who arrived on campus with a dream to inspire change and generate new ideas. We believe that true progress is made when different perspectives come together to advance our understanding of the world around us. And we enlighten our communities and point the way to a better future. At UCI, we shine brighter.
ABOUT THE SCHOOL OF MEDICINE
Ranked as one of the top 50 U.S. medical schools for research by U.S. News & World Report, UC Irvine Health School of Medicine is dedicated to advancing medical knowledge and clinical practice through scholarly research, physician education, and high-quality care.
The medical school nurtures the development of medical students, resident physicians, and scholars in the clinical and basic sciences and supports the dissemination of research advances for the benefit of society.