The Laboratory of Molecular Biology at The Rockefeller University is seeking a highly motivated and outstanding candidate for a postdoctoral position to study the selective vulnerability and degeneration of upper motor neurons in amyotrophic lateral sclerosis (ALS). ALS presents a paradox in that most known disease-causing mutations are ubiquitously expressed, yet only discrete populations of cells degenerate. We therefore use a multidisciplinary approach, centered on advanced molecular profiling methods to elucidate cell type-specific phenotypes during disease progression in preclinical mouse models and postmortem human tissue. By contrasting vulnerable and resilient neuronal populations as well as non-neuronal cells, we hope to identify novel disease mechanisms and putative entry points for therapeutic intervention These studies are also integrated with modern anatomical and circuit-tracing methods and behavior to map the identity, connectivity, and function of neuronal cell types in cortical and motor circuits.
The ideal candidate will have a Ph.D. in neuroscience or a related field and have prior research experience in molecular or cellular biology. Preference will also be given to those with familiarity with at least one of the following: next generation sequencing, quantitative analysis of sequencing data, animal models of CNS disorders, neuroanatomy and immunohistological methods, and/or functional circuit-mapping. Candidates must also demonstrate a strong track record of research productivity, scientific rigor, excellent communication skills, and an ability to work both independently and as part of a team.
Interested applicants should send a cover letter, CV, and names and contact information of three (3) references to Dr. Eric Schmidt (email@example.com). Applications will be accepted until the position is filled.
Internal Number: ES20181105
About The Rockefeller University
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