General Information: The Stefan Pulst / Daniel Scoles Neurology Laboratory group at the University of Utah, Department of Neurology, invites applications for a postdoctoral fellowship for the study of cerebellar ataxia and other neurodegenerative diseases using calcium imaging and electrophysiological recordings. The Neurology Laboratory is well-funded by NIH, and other funding sources. We seek a highly motivated PhD in a related medical science who is interested in carrying out research on how RNA granules control localized calcium abundance and neuronal function in cultured cells and acute brain slices. The research objectives include understanding mechanisms of neurodegenerative disease as well as testing novel therapeutics in disease models.
The postdoc will join a well-established research program focused on developing therapeutics for cerebellar ataxia, amyotrophic lateral sclerosis, and other neurodegenerative disorders. The cellular mechanisms underlying these neurodegenerative diseases will be evaluated using a combination of two-photon imaging to monitor calcium abundance changes, live imaging for monitoring the movement of RNA granules, and electrophysiological recordings.
Located on the upper campus of the University of Utah, the position offers exceptional opportunities for interdisciplinary collaboration with a diverse group of investigators in both the Department of Neurology and the College of Pharmacy with a wide range of interests relative to the area of investigation, and a rigorous focus on developing therapeutics for neurodegenerative diseases.
Specific tasks: The postdoctoral fellow will perform electrophysiological recordings from patch clamped cerebellar Purkinje neurons with simultaneous two photon imaging of calcium levels and markers for stress granules in dendrites. Initial studies will utilize SCA2 mouse models. Opportunities will be available to utilize ALS models.
Qualifications: Applicants should be highly motivated, have a Ph.D., at least 1 year of experience with extracellular or patch-clamp electrophysiology in acute brain slices. Experience with two-photon imaging would be a plus. Other requirements include laboratory, analytical, and organizational skills, verbal and written communication skills, and the ability to work in a team.
Responsibilities: The postdoc will plan, design, and conduct experiments that are related to the project. Experiments may involve classical cell and molecular biology techniques, cloning, transfection, cell culture assays, AAV gene delivery in mice, electrophysiological recordings, and two-photon imaging.
Additional Salary Information: Annual salary estimated and negotiable.
Internal Number: PRN18147B
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