The newly established Neuroscience and Imaging Thematic Department is focused on identifying and developing novel therapies for neurodegeneration. We are concentrating on mechanisms, pathways and targets that are known through genetics to play causative roles in human disease and whose modulation is expected to be disease modifying. A main strategy of our group is to develop partnerships with external leaders in technology and biology to build a world class drug discovery portfolio. In addition, we collaborate within Celgene to utilize our industry-leading understanding of protein degradation to identify and develop innovative medicines for neurodegeneration.
We are seeking a talented postdoctoral fellow in the Neuroscience group based in Cambridge, MA to be part of a new and growing neuroscience team at Celgene and have the opportunity to creatively apply state of the art technologies to the study of neurodegeneration and gene regulation. The PostDoc will be responsible for developing research projects aimed at identifying mechanisms of regulation of genes involved in neurodegeneration and neuroinflammation. In particular, the candidate will have the opportunity to develop large scale genetic and chemical biological approaches for identifying key regulatory nodes in expression and pathologic aggregation of genes driving neurodegeneration.
Responsibilities will include, but are not limited to, the following:
Design of next generation systematic screens for regulators of gene expression and protein aggregation.
Design and execution of high throughput genetic screens.
Characterization of novel regulators of neural differentiation, survival, neuroinflammation and protein homeostasis.
Internal Number: 02140
Celgene Corporation is committed to delivering innovative therapies designed to improve the lives of patients worldwide. We are a global biopharmaceutical company with operations in more than 70 countries that is helping to turn incurable cancers into chronic, manageable conditions. We are seeking talented professionals as we continue to grow and advance our efforts in oncology, hematology and immune and inflammatory disease. If you would like to join a company where you can make a difference, please consider Celgene. Please visit our website at www.celgene.com.