The CNS is responsive to an ever-changing environment. Studies of neural circuit plasticity focus almost exclusively on functional and structural changes of neuronal synapses. In recent years, however, myelin plasticity has emerged as a potential modulator of neuronal networks. Myelination of previously unmyelinated axons and changes in the structure on already-myelinated axons (e.g. changes in internode number and length, myelin thickness, or geometry of the nodal area) can have large effects on the function of neuronal networks. It is conceivable that, as for in neuronal synapse plasticity, myelin changes are regulated by a change in the frequency of neuronal firing. However, to what extent myelin modifications occur in the adult, and the underlying mechanisms, are currently unclear.
We are looking for a motivated, and independent research associate with proactive and flexible attitude to work to join a European Research Council (ERC) funded research project to uncover to what extent myelin plasticity occurs and the mechanisms underlying it.
The Karadottir lab aims to understand (1) how neurons regulate oligodendrocyte progenitor cell differentiation throughout life in both health and disease; and (2) the effect myelin has on neuronal circuits. The lab uses a combination of diverse approaches, including molecular, genetic, cellular, imaging, physiological and behavioural methods in order to achieve a detailed understanding of myelin plasticity.
Requirements: We are looking for candidates, with a PhD level qualification in the field of neuroscience. Candidates with experience in electrophysiology, and/or in vivo optogenetics, imaging, or behavioural tests are particularly encouraged to apply.
We are specifically looking for candidates who are collaborative with effective communication skills and enjoy working in a team and are interested in the Karadottir lab.
Internal Number: PS17293
About University of Cambridge
The University of Cambridge is one of the world’s oldest and most successful universities. We are a renowned centre for research, education, and scholarship that makes a significant contribution to society. The University is consistently ranked amongst the top universities in the world. Our affiliates have won more Nobel Prizes than any other University.
The Cambridge Stem Cell Institute is a world-leading centre for stem cell research with a mission to
transform human health through a deep understanding of stem cell biology. Our scientists study stem cell behaviour, both normal and pathological, and use their findings to improve the prevention, diagnosis and treatment of diseases.
Our Institute currently consists of 30 outstanding research groups, working across three key research themes: Stem Cell States, Stem Cells in Disease and Stem Cells & Therapeutics.