NIMH funded positions to study basic mechanisms regulating gene expression in developing GABAergic interneurons in mice. We use state of the art molecular and genetic tools to study how the Evf2 long non coding RNA controls gene expression through control of enhancer-target gene positioning. We recently published that Evf2 functionally and spatially organizes a group of genes that regulates genes linked to specific GABAergic interneuron subtype genes. This work links mevalonate pathway, serotonin receptor gene regulation, and seizure susceptibility for the first time (see Cajigas et al 2018 Molecular Cell 71. 956-972). Our work on Evf2, the first enhancer long non coding RNA spans several years beginning with Feng et al. 2006 Genes and Development 20:1470-84, Bond et al. 2009 Nature Neuroscience 12:1020-7,Berghoff et al. 2013, Development 140: 4407-16, and Cajigas et al. 2015 Development 142:2641-52. For those attending SFN2018, please see poster A10 Mon Nov 5th 9-10am for further details on our work.
We are looking for highly motivated scientists.
Post doctoral applicants interested in pursuing academic careers in neuroscience, development, seizure models, novel molecular methods, biochemistry, or genetics, with PhD background in any of these fields should apply.
Research scientists with BA/MS in biology, biochemistry, chemistry, molecular biology/genetics can apply, with a minimum of a two year commitment.
Additional Salary Information: Institutionally determined for Research technicians
Internal Number: 1
About Northwestern Feinberg School of Medicine
Northwestern Feinberg School of Medicine provides a diverse and interactive neuroscience and basic science community. My lab will be located in the newly built Simpson Querry Research Center, a state of the art research facilities in downtown Chicago (Streeterville campus). I am an NIMH funded investigator at NUFSM. My lab studies novel mechanisms regulating GABAergic interneuron development, focusing on the long non coding RNA Evf2, discovered in my lab in 2006 (Genes and Dev), reported in Nature Neuroscience (2009) and recently featured on the cover of Molecular Cell (2018) 71, 956.