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SENIOR SCIENTIST - SAFETY AND EXPLORATORY PHARMACOLOGY
West Point, PA Job #PHA001478
The Senior Scientist (Safety & Exploratory Pharmacology Department, SEP) is a skilled and highly motivated scientist with subject matter expertise in integrative neuroscience (more particularly: EEG with emphasis on seizure/convulsion), and/or cardiovascular preclinical in vivo physiology/pharmacology. The successful candidate must also possess proven, strong experimental, functional laboratory, and collaborative leadership characteristics with knowledge and experience in the conduct, analysis, development, and interpretation of a broad range of in-vivo endpoints and chronic instrumentation approaches relevant to non-GLP investigative safety pharmacology.
Under the direction and supervision of senior SEP department management, his/her primary responsibilities include: collaboration within a team for the development and conduct of complex preclinical in-vivo assays used for investigative risk assessment and routine lead optimization of new drug candidates in discovery and preclinical development. He/she will contribute to the design and conduct of well-defined non-GLP studies in different preclinical test systems. He/she will also conduct assigned complex laboratory tasks that include the development of new models, physiologic data recording, data handling/analysis, timely summarization and interpretation of data, and writing reports.
- The successful candidate will report to the Director of In Vivo Investigative Safety Pharmacology. This scientist will demonstrate critical problem-solving skills, ability to analyze complex data sets and when required to propose new model development and/or new endpoints/analyses methods for NBEs or NCEs. - Primary objectives include: i) direct laboratory contribution to the conduct of investigative preclinical, in-vivo, non-GLP risk assessment studies designed to provide critical information on major vital organ systems with an initial focus on nervous system endpoints: ii) model development, including refinement of existing approaches and/or implementation of new methods and physiologic endpoints iii) ability to integrate preclinical in vivo functional assessments into a broader interpretation of systemic risk; iv) provide a mechanistic understanding of the observed profile. - The successful candidate is expected to work independently and collaborate as part of a cross functional team. Successful interaction with co-workers within the SEP department and other groups within Merck & Co. as well as contribution to the functional and strategic effort of specific programs is required. - In this role, an extensive understanding of in-vivo study execution of complex invasive and non-invasive preclinical methodologies in central &/or peripheral nervous system (CNS & PNS) is required and cardiovascular experience is strongly preferred. In addition it is preferred that the successful candidate be functionally adept in analysis tools including familiarity with programming /building tools in MatLab, Excel VBA, R, IronPython, or other. - Possibility to participate in national and/or international professional societies/technical associations/working groups with presentation of original work at internal or external scientific meetings/conferences. Also, direct contribution and authorship/co-authorship of scientific publication(s) in peer-reviewed journals is strongly desired.
Education Minimum Requirement:
- Bachelor's Degree in Biology or related discipline with at least 7 years of experience. - Master's Degree in Biology or related discipline with at least 4 years of experience. - Ph.D in Biology or related discipline.
Required Experience and Skills:
- Experience in the development, execution and interpretation of in-vivo studies with a focus on the CNS/PNS or cardiovascular system. - Proven ability to develop and conduct complex, integrated in vivo studies in conscious rodents and non-rodent laboratory species targeting endpoints in the CNS/PNS with additional experience in cardiovascular a plus. - Significant data acquisition, analysis, and signal processing skills, including previous experience in using multiple analysis/reporting tools.
Preferred Experience and Skills:
- 1-3 yrs postdoctoral experience in the development, execution and interpretation of in-vivo studies preferred. - Previous experience in the use of radiotelemetric approaches of continuous measurement and recording of CNS &/or PNS endpoints in conscious, freely moving animals. Additional in-vivo experience in cardiovascular and/or at least one other vital organ system preferred.
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