Postdoctoral Fellow Epilepsy - Cell Loss, Circuit Reorganization and GABA Receptors University of California, Los Angeles (UCLA)
A Postdoctoral fellow position is available for a qualified and motivated researcher with strong interests in Basic Mechanisms of Epilepsy, including cell loss, circuit reorganization and GABA-A receptors. The position will include developing and utilizing novel, cutting edge methods for studying seizure development and progression in mouse models of epilepsy. Studies in the Houser Neurobiology laboratory are focused on 1) the effects of ablation of specific groups of hippocampal neurons on the reorganization of hippocampal circuitry and the potential development of epilepsy; and 2) the effects of changes in tonic inhibition in the hippocampus in a mouse model of epilepsy.
One broad project focuses on the effects of ablation of specific groups of Cre-expressing hippocampal neurons on epileptogenesis and seizure susceptibility. The applicant should have experience in stereotaxic injections and EEG and depth recordings in freely-behaving rodents. The goal is to determine the effects of such selective ablations on plasticity and circuit activity within the hippocampus, utilizing silicon-based probes with microelectrode arrays in vivo; Ca imaging with miniscopes; and immunohistochemical studies of surviving hippocampal neurons and their projections.
A second project will utilize transgenic mice and viral transfection of specific GABAA receptor subunits in selected neurons of the dentate gyrus to modify network activity. The project is multifaceted and will include 1) in vitro studies of tonic inhibition in hippocampal slices; 2) in vitro and in vivo recording of seizure activity; and 3) immunohistochemical studies of GABAA receptor subunit expression.
Projects will be conducted through collaborative work with Drs. Carolyn Houser, Istvan Mody and Peyman Golshani.
UCLA, including the David Geffen School of Medicine at UCLA, is an exciting and dynamic center for Neuroscience research and is ideal for a Postdoctoral fellowship or related position. The Neuroscience community is highly interactive, and the environment is rich with seminars, symposia and collaborators, offering exposure to cutting edge techniques and stimulating scientific discussions.
Applicants should contact: Carolyn Houser, Ph.D. Department of Neurobiology David Geffen School of Medicine at UCLA Los Angeles, CA 90095 email@example.com (Please contact by email)
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy. (http://policy.ucop.edu/doc/4000376/NondiscrimAffirmAct)
Qualifications 1) Ph.D. in Neuroscience or related field. 2) Demonstrated background, preferably with publications, to show a track record in epilepsy-related or GABA-A receptor research. 3) Experience with the following methods:
EEG and depth recordings and analysis of epileptiform activity in freely-behaving rodents.
Stereotaxic surgery (hippocampus).
Confocal microscopy and morphological analysis.
In vitro electrophysiological recording in hippocampal slices.
(Experience with at least 3 of the above methods is required, with interest in learning additional.)
4) Interest in developing and using new methods in the laboratory, including recording with silicon-based probes with microelectrode arrays in vivo; optogenetic methods; and Ca imaging with miniscopes. 5) Experience with mouse colony management and rodent behavior. 6) Good verbal and written communication skills in English. 7) Strong organizational skills. 8) Ability to work well with a team.
Internal Number: SFN1
About David Geffen School of Med UCLA
The David Geffen School of Medicine at UCLA is located on the University of California, Los Angeles, campus. UCLA is a dynamic center for Neuroscience research that includes the Department of Neurobiology and Brain Research Institute. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy. (http://policy.ucop.edu/doc/4000376/NondiscrimAffirmAct)