A federally funded position is available for a Postdoctoral Fellow in the Department of Pharmacology in the Lab of Dr. William Birdsong. Join our team as we build our lab studying the role of opioids such as morphine in modulating pain and addiction circuitry using electrophysiological and imaging approaches.
The suitable candidate will be required to perform stereotaxic surgeries on mice or rats, prepare acute brain slices and obtain whole-cell electrophysiological recordings. There will be opportunities to carry out projects involving 2-photon and confocal microscopy. Additionally, multiple labs in the Department of Pharmacology pursue cutting-edge opioid research with molecular, cellular, circuit, and behavioral foci providing the opportunity for collaboration.
A PhD in neuroscience, pharmacology or related field and a record of carrying out creative independent research is required.
A background in electrophysiology or drug abuse research is preferred. Evidence of presentation(s) at national/international meetings and application or awarding of pre-doctoral fellowship awards is a strong plus.
Internal Number: 162958
About University of Michigan Department of Pharmacology
Opioids are both effective at treating chronic pain and, as the current opioid overdose epidemic has shown, are clearly addictive and deadly. The relief of pain can itself be rewarding, demonstrating the intimate interaction between pain and reward. This pain/ reward circuitry, known as the affective pain system, mediates the emotional and motivational aspect of pain perception promoting behaviors that will relieve pain and avoid potentially painful behaviors and situations. Work in the Birdsong lab focuses on elucidating mechanisms of modulation of synaptic circuitry induced by both acute and chronic opioid treatment in central nervous system pain circuits.
To do this we use a virally delivered optogenetic approach with acute brain slice electrophysiology and imaging to analyze long and short-range circuit connectivity and the effects of opioids in modulating this circuitry. This work takes advantage of the excellent pharmacology of opioid receptors subtypes to differentiate the roles of the three different subtypes of opioid receptors (mu, delta, and kappa) in modulating affective pain circuitry.
The Birdsong lab is part of the Department of Pharmacology at the University o...f Michigan. We are a collaborative group of scientists using cutting-edge techniques to study questions related to the actions and effects of drugs in the context of neuroscience, cardiovascular physiology, and cancer biology and are seeking other motivated scientists to join our team.