The Aoto lab laboratory has funded projects from NIH and BBRF investigating the molecular mechanisms that control synaptic transmission in brain circuits relevant to neuropsychiatric diseases and addiction disorders (www.aotolab.org). Specifically, we are currently interested in assessing the role of trans-synaptic cell adhesion molecules at synapses in these distinct brain circuits. To dissect these circuits and understand their molecular underpinnings, we use a multidisciplinary approach that consists of electrophysiology, molecular biology, mouse genetics, in vivo stereotaxic injections of viral vectors, single-cell RNA-sequencing and optogenetics. We are seeking a passionate, dedicated, honest and hard-working postdoctoral fellow who has experience with electrophysiology.
A postdoctoral fellow will be responsible for:
1) Research conceptualization - with guidance from the PI, the fellow will be expected to take the lead role in designing and implementing experiments.
2) Performing research - independently perform experiments (electrophysiology, calcium imaging, brain clearing/lightsheet microscopy) and maintain mouse lines pertinent to the research (e.g. mouse husbandry). Electrophysiology is the only technique required.
3) Data Analysis - timely analysis of data and generation into formats presentable for presentations and peer-reviewed journal articles. Accurate note-taking is essential.
4) Preparation of manuscripts - generation of tables and figures for publication.
5) Mentor junior graduate students.
Qualified applicants must electronically submit a cover letter, curriculum vitae and 3 references HERE. Please note in your cover letter if you will be attending SfN2018 in San Diego.
Special Notices to Applicants:
The University of Colorado Denver | Anschutz Medical campus is committed to providing a safe and productive learning and living community. To achieve that goal, we conduct background investigations for all final applicants being considered for employment. Background investigations include a criminal history record check, and when appropriate, a financial and/or motor vehicle history.
The Immigration Reform and Control Act requires that verification of employment eligibility be documented for all new employees by the end of the third day of work. The University of Colorado strongly supports the principle of diversity. We encourage applications from women, ethnic minorities, persons with disabilities and all veterans. Alternative formats of this ad are available upon request for persons with disabilities.
Please be advised that the University does check references as part of the employment process, and selection committee members may choose to contact work references during the search process other than those listed in your application.
The University of Colorado is committed to diversity and equality in education and employment.
1) This position requires a PhD in neuroscience, neurophysiology or related field.
2) Prior experience with electrophysiology is required
3) Excellent writing skills
4) Create and independent with excellent communication skills
1) Strong work habits and ability to work independently
2) Experience with molecular biology and mouse genetics is preferred
3) Tissue culture of mammalian cells
4) Experience with in vivo stereotaxic injections
5) Experience handling mice
6) Strong research record as demonstrated by publications in peer-reviewed journals
Internal Number: A0002
About University of Colorado Denver
The Aoto lab is one of 15 neuroscience laboratories in the Department of Pharmacology at the University of Colorado, Denver. The multidisciplinary and highly collaborative laboratories in the Department of Pharmacology use classical and cutting-edge approaches that consist of electrophysiology, high-resolution microscopy, animal behavior, biochemistry and molecular biology to address fundamentally important molecular neuroscience questions. Our lab utilizes optogenetics, stereotaxic injections of virus in vivo to functionally trace circuits and/or manipulate gene expression, novel mouse genetics, molecular biology, next-generation single-cell RNA sequencing and electrophysiology to dissect synaptic molecule function in the brain circuits relevant to neuropsychiatric disorders with cell-type and synapse-specific resolution. Our main interest is to interrogate the roles of disease-relevant trans-synaptic cell adhesion molecules in microcircuits and projection circuits related to disease.