Postdoctoral Fellow: Molecular Mechanisms Underlying Social Memory
Virginia Tech Carilion Research Institute
October 5, 2018
Commensurate with Experience
Full Time - Experienced
Academic / Research
Research in the Farris lab at the Virginia Tech Carilion Research Institute (VTCRI) focuses on understanding how dendritically localized RNAs are regulated in the brain and how local translation promotes cell-type specific functions underlying learning and memory. In particular, we are currently focused on investigating dendritic RNAs in area CA2 of the hippocampus, a subregion that is resistant to long-term potentiation and cell-death, and is thought to be required for social memory. Given that a number of neurodevelopmental disorders are characterized by disruptions in social processing, investigating the post-transcriptional mechanisms critical to CA2 function and gaining a comprehensive molecular understanding of how social experiences are stored in the brain may lead to novel therapies relevant for individuals with social deficits.
Using a combination of mouse genetics to gain access to specific hippocampal cell-types, deep sequencing technologies to obtain a genome-wide view of transcription and translation, and single molecule imaging techniques to illuminate the processes regulating dendritic RNA in vivo, we hope to provide mechanistic insight on the behaviorally-induced synaptic modifications in CA2 that may be required for encoding social behavior.
A postdoctoral associate will be responsible for: 1. Research Conceptualization – With the guidance of the PI, take a lead role in the design of experiment methodology and methods. 2. Perform Research — Independently perform experiments using techniques including mouse behavior, next generation sequencing, high resolution confocal imaging on thick brain sections (expansion microscopy/tissue clearing), slice electrophysiology, and calcium imaging. Note that experience in one or more of these techniques is not required, but desirable. 3. Data Analysis – Analyzing the findings from research methods and transforming the results into formats appropriate for dissemination in peer reviewed publications or conference presentations or in formats that engender further analysis. 4. Research Publications – Preparation of text, tables, and graphical information as appropriate for dissemination in peer-reviewed publications, or presentation at professional conferences. 5. Mentor undergraduate students.
Qualified applicants must electronically submit online application, cover letter, resume/curriculum vitae, and list of 3 professional references to jobs.vt.edu. Apply to posting SR0180168. Applicant screening will continue until the position is filled. Virginia Tech is committed to building a culturally diverse faculty and strongly encourages applications from women and minorities.
Virginia Tech is an Equal Opportunity/Affirmative Action employer.
If you are an individual with a disability and desire an accommodation please contact the hiring department with any questions.
Required Qualifications: 1. PhD in molecular, cellular, or computational biology, pharmacology, physiology, neuroscience, or a related field. 2. Excellent writing skills; particularly with respect to report writing and editing. 3. Creative, independent with excellent communication skills.
Preferred Qualifications: 1. Strong work habits and the ability to work independently as well as in a fast-paced research environment with a team 2. Strong research record as demonstrated by publications in peer-reviewed journals. 3. The ideal candidate for this position should have demonstrated experience (i.e. publications) in neuroscience, RNA biology, or computational biology
Internal Number: SR0180168
About Virginia Tech Carilion Research Institute
The Virginia Tech Carilion Research Institute is one of Virginia Tech’s three thematic research institutes. It opened on Sept. 1, 2010, welcoming new faculty, postdoctoral fellows, students, and staff from across the United States and throughout the world. It grew rapidly to 26 research teams with more than 300 faculty, staff, and students by 2017 and almost $100 million in extramural research grant funding, primarily from the National Institutes of Health.
Based in Roanoke, Virginia, the institute was designed to accommodate interdisciplinary research to address contemporary challenges in health and disease through combinations of biological, behavioral, computational, and engineering approaches.
Key research focus areas include addiction and substance abuse, behavioral health, cardiovascular science, cancer including structural oncology, cognitive and computational neuroscience, decision-making, developmental and translational neurobiology, human development, neurorehabilitation, immunology, and regenerative/restorative medicine.