Targeting Nrf2 for the Treatment of Neurodegenerative Diseases
University of Wisconsin
September 19, 2018
NIH postdoctoral stipend level
Full Time - Entry Level
Academic / Research
A postdoctoral position is presently available in the laboratory. The focus of the laboratory is Molecular Neuropharmacology/Neurodegeneration. Oxidative stress is believed to be a principal factor in the development of many chronic neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s and Amyotrophic Lateral Sclerosis. My laboratories goal is to discover ways to increase the defense mechanisms in brain by activating multiple antioxidant defense genes simultaneously through activation of the Nrf2-ARE pathway. Present work in the laboratory is focused on: 1) signaling mechanisms responsible for Nrf2-mediated neuroprotection using proteomics and RNAseq; 2) role of astrocytes in Nrf2-mediated neuroprotection; 3) the role of Nrf2 in microglial activation; and 4) viral-mediated delivery of Nrf2 and/or transplantation of Nrf2 into animal models of Alzheimer’s and Parkinson’s Disease.
Please contact: Jeffrey A. Johnson, Ph.D., University of Wisconsin, Phone: (608) 262-2893; e-mail: email@example.com
A Ph.D. in neuroscience or related field. Experience with transgenic animals and primary culture systems including iPSC.