The NIH-funded Nakazawa lab is seeking an independent-thinking, highly motivated postdoctoral fellow to study in the Neuroscience Department at Southern Research (SR). Our research is focused on identifying the neurodevelopmental origin of schizophrenia pathophysiology, leading to the final common pathway of symptom emergence, such as evoked gamma oscillation deficits and dopamine release abnormalities in the striatum and cortex. We recently found that hypo function of N-Methyl-D-aspartate (NMDA)-type glutamate receptor (NMDAR) in immature cortical GABA neurons may be one such upstream pathway. Currently, the Nakazawa lab is particularly interested in: (1) the functional role of NMDARs in cortical fast spiking neurons; (2) identifying the perinatal abnormalities leading to cortical GABAergic dysfunction; and (3) the circuitry mechanisms of hyper-excitable auditory cortex.
The postdoctoral fellowship position suits candidates highly motivated to perform the whole-cell patch-clamp recordings in mouse brain slices to understand the role of cortical and hippocampal GABA neurons in the schizophrenia pathophysiology. Candidates should be capable of performing the ex vivo recording from cortical fast-spiking neurons and must demonstrate abilities to think independently and work collaboratively.
Prospective candidates must include with their application a single PDF with the following: (1) a statement of interest describing research experience and future goals; (2) curriculum vitae; and (3) contact information for two references who will provide letters of support.
Ph.D. in neuroscience or relevant scientific discipline
Experience in neuroscience and/or neuropsychiatry-related field
Interest in understanding neuronal circuitry function
Experience with mouse and rat behavioral testing and related statistical analyses
Strong background in electrophysiology, neuroanatomy, microscopy, and rodent behavioral testing
Proven ability to work in a collaborative, team environment
Excellent verbal and written communication skills
Competency in Microsoft Office Suite products and other relevant software
Knowledge of use of protective equipment and safety protocol related to handling hazardous materials
Ability to observe appropriate safety and study requirements by reading, understanding, and following standard operating procedures (SOPs) requirements and study protocols.
Ability to learn and perform delicate surgical procedures
Developmental neurobiologist with expertise in handling of perinatal mouse brain organs
Commitment to the development of a dynamic career in science
Internal Number: 3349
About Southern Research
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Founded in 1941, Southern Research (SR) is an independent, 501(c)(3) nonprofit, scientific research organization with more than 400 scientists and engineers working across four divisions: Drug Discovery, Drug Development, Engineering, and Energy & Environment. SR supports the pharmaceutical, biotechnology, defense, aerospace, environmental, and energy industries as we work on behalf of the National Cancer Institute, National Institutes of Health, the U.S. Department of Defense, the U.S. Department of Energy, NASA, major aerospace firms, utility companies, and other private and gove...rnment organizations. We pursue entrepreneurial and collaborative initiatives to develop and maintain a pipeline of intellectual property and innovative technologies that positively impact real-world problems. SR is headquartered in Birmingham with additional laboratories and offices in Wilsonville, Alabama; Frederick, Maryland; Durham, North Carolina; Cartersville, Georgia; and Houston, Texas.