The Seal lab studies neural circuits related to pain (Peirs, Williams et al Neuron 2015, Peirs and Seal, Science 2016) and to Parkinson's disease (Divito et al, J. Neurosci 2015). We were awarded NIH funding to determine the molecular and cellular organization of the primate dorsal horn by single cell transcriptome, RNAscope in situ hybridization and histochemical analyses. The project will compare the organization of this more advanced species to the recent single cell sequencing efforts performed in mouse (Häring et al, Nature Neurosci, 2018 and Sathyamurthy et al, Cell Report 2018). Information obtained from the study will be used to design cell-specific viral tools for circuit studies in primates and as novel therapeutics.
This is an excellent opportunity for someone who wants a career as principal investigator in academia or who wants to go to industry. You will be part of a culture that values hard work, intellectual curiosity, creativity, innovative thinking and teamwork, thus making it a wonderful place to grow and develop professionally.
PhD in Neurobiology, Cell Biology, Molecular Biology or related.
Strong experience in molecular biology required. Knowledge of bioinformatic analyses and/or interest in therapeutics is a plus.
Internal Number: 82018
About Neurobiology Department
A large and vibrant neuroscience community that includes the Pittsburgh Pain Center, the Brain Institute and the Center for Neural Basis of Cognition