Postdoctoral Associate in Synapse/Circuit Regulation by Autism Genes
UT Southwestern Medical Center
July 30, 2018
Full Time - Experienced
Academic / Research
We are seeking to fill one or more postdoctoral positions in the Department of Neuroscience at UT Southwestern Medical Center in Dallas, TX. Successful candidates will perform research in the functional analysis of synapse and circuits by genes linked to autism (e.g. Fmr1, Mef2c and Foxp1), and in preclinical autism models. Projects are funded by multiple federal and foundation grants to identify the cellular, synaptic, circuit and neural network mechanisms by which autism genes regulate development, function and plasticity of cortical and striatal circuits. Techniques will primarily employ electrophysiology; whole cell patching and extracellular recordings of synaptic and circuit activity in brain slices using laser-guided circuit mapping techniques, including optogenetics, and state-of-the-art genetic manipulation techniques (see Rajkovich, et al., Neuron, 2017). With collaborators, projects also will determine the effects of autism genes on the transcriptome and translatome in neurons to link molecular mechanisms with functional circuit changes. Researchers will work in the collaborative research environment of the laboratories of Kimberly Huber, PhD (https://www.utsouthwestern.edu/labs/huber/) and Jay Gibson PhD (https://www.utsouthwestern.edu/labs/gibson/), where we incorporate state of the art molecular and biochemical methods with sophisticated functional analysis of circuits to understand the cellular mechanisms by which autism genes affect brain function and utilize this knowledge to identify therapeutic targets. The Huber/Gibson lab is also part of a NIH Center for Collaborative in Fragile X, (http://www.utsouthwestern.edu/labs/fragile-x/), which is comprised of a team of investigators at 3 sites across the US that work in a multilevel, integrated approach to determine mechanisms of sensory neocortical dysfunction in humans with fragile X syndrome (FXS) and in preclinical mouse models of FXS. UT Southwestern is a premier research facility with state of the art core facilities and extensive career development opportunities for Postdoctoral Fellows.
To apply, please send a CV, brief description of research interests and contact information of references to Drs. Kimberly Huber (Kimberly.Huber@UTSouthwestern.edu) and Jay Gibson (Jay.Gibson@UTSouthwestern.edu).
UTSouthwestern Medical Center is an Affirmative Action/Equal Opportunity Employer. Women, minorities, veterans and individuals with disabilities are encouraged to apply.
A PhD in Neuroscience or related field is required. Experience in either electrophysiology or molecular biology is preferred, but not necessary.
Internal Number: KH_JG_01
About UT Southwestern Medical Center
As one of country’s top medical schools and the only academic medical center in North Texas – with a faculty boasting 6 Nobel Prize winners – UT Southwestern Medical Center is proud to be recognized as one of the world’s foremost research institutions, and excited to offer research professionals the resources, support and funding to produce breakthrough work with global implications.
The Peter O’Donnell Jr. Brain Institute is a comprehensive center dedicated to better understanding the basic molecular workings of the brain and applying those discoveries to prevention and treatment of brain, spine, nerve and muscle disorders.