Postdoc (5 yrs funding) in Neuron Dev & Cell Biol: delta-Catenin in shaping Neurons/ Dendrites
Dept Genetics, University of Texas MD Anderson Cancer Center
July 18, 2018
NIH pay scale.
Full Time - Entry Level
Academic / Research
delta-Catenin and the shaping of Neurons/ Dendrites.
An intriguing question that reflects upon the formation and function of the CNS is how dendrite shapes are determined. Such choices influence how dendrites interact with axons and other cells, and thus the wiring and function of the brain. We find that delta-catenin, through phospho-dependent associations with either of two novel protein partners, affects the morphology of dendrites towards either branching or lengthing.
By employing primary rat hippocampal cultures as well as Xenopus embryos to assess in vivo outcomes, we propose to identify both the upstream pathways involved (e.g. ligands and kinases), and the downstream mediators (e.g. cytoskeletal modulators) that promote these dramatic branching versus lengthening outcomes. Thus, our work aims to advance understanding of normal neuron development. Each of the three proteins being examined are further implicated in neuro-developmental disorders.
Environment. The PI values and has been recognized for his contributions to trainee mentorship. Within the Texas Medical Center, MDACC provides world-class resources and opportunities, and we enjoy walking access to other strong institutions (Baylor SOM, Rice U, Methodist RI, UTHealth, & TX A&M IBT). Houston is a strikingly multicultural, affordable and cosmopolitan city that adjoins the Gulf of Mexico.
An inquisitive, imaginative, productive and considerate individual is sought, who recently received their PhD in neuroscience, development and/ or cell biology.
We have funding to support a beginning postdoctoral fellow for 4-to-5 years. We are looking for an individual who will minimally commit to four years with us, advancing their training and career prospects while improving the field's understanding of how catenins and their associated proteins regulate dendrite shapes and functions.
Internal Number: 1
About Dept Genetics, University of Texas MD Anderson Cancer Center
The PI and his group are seeking to understand the roles of two novel delta-catenin complexes which promote the shaping and functioning of neuronal dendrites.The PI's laboratory is known for its work upon the developmental/ cellular contributions of less understood catenins, which have been found to have wide ranging essential functions. The PI is interested in and has been recognized for mentorship. The University of Texas MD Anderson Cancer Center, together with other well known institutions in the Texas Medical Center, offer a vibrant scientific environment with long term career possibilities. As a city, Houston is an stimulating and multicultural metropolitan center located inland from the Gulf of Mexico. Affordable housing is available close to our Texas Medical Center, which notably adjoins Houston's museum district (Museum of Fine Arts, Contemporary Arts Museum, Asia Society, Museum of Natural Science, Childrens' Museum), as well as green spaces within Hermann Park (McGovern Lake, Japanese Garden, Zoo, Golf Course, Miller Outdoor Theatre) and the campus of Rice University.