Department of Neuroscience and Pediatrics, Albert Einstein College of Medicine
June 1, 2018
Bronx, New York
NIH Salary Range
Full Time - Experienced
Academic / Research
An outstanding and highly-motivated post-doctoral fellow is sought to participate in translational research on intraventricular hemorrhage of premature infants. The ideal candidate should have fewer than five years of postdoctoral experience and a strong publication record in the field of developmental neurobiology/neuroscience.
Our lab is focused on understanding the pathogenesis of intraventricular hemorrhage (IVH) in preterm infants and developing strategies to minimize brain injury in the survivors of IVH. Ongoing interests include evaluating glutamatergic and GABAergic neurogenesis in preterm infants with IVH and employing genetic and pharmacological approach to restore production of cortical neurons and interneurons and neurological function in premature rabbit and P1 mouse model of IVH. The lab also uses autopsy samples from premature infants with and without IVH. There is an opportunity to learn new skills, including confocal microscopy, stereology, Two-photon microscopy diolistic staining, NeuronStudio, Neurolucida 360, neurobehavior and more.
Please contact Praveen.email@example.com (Phone 914-953-1936) with inquiries and applications.
postdoctoral fellowship: less than 5 years
Additional Salary Information: Salary is competitive and commensurate with experience and contribution (NIH salary range).
Internal Number: 29
About Department of Neuroscience and Pediatrics, Albert Einstein College of Medicine
Our laboratory studies the pathogenesis of intraventricular hemorrhage (IVH) and evaluates neuro-protective strategies to prevent brain injury after IVH in premature infants. The major projects in our laboratory are focused on determining a) the mechanisms underlying white matter injury in premature infants with IVH and approaches to minimize the damage, b) the effect of IVH on glutamatergic neurogenesis and corticogenesis in the developing brain, and strategies to restore these processes, and c) the effect of prematurity on neurogenesis and corticogenesis.
To answer our research questions, we employ a preterm rabbit model (in vivo studies) and an in vitro organotypic forebrain slice culture model of IVH. Our glycerol model of IVH in preterm rabbits exhibits periventricular white matter injury and post-hemorrhagic hydrocephalus similar to that seen in human preterm survivors with IVH. In addition, we analyze autopsy samples from preterm infants with and without IVH. Commonly used techniques include Immunohistochemistry, confocal microscopy, stereological quantification of neural cells, Western blot analyses, real time qPCR, slice culture, neuronal migration studies, viral gene transfer, flow-cytometry, and magnetic bead isolation of cells.