An outstanding POSTDOCTORAL RESEARCH ASSISTANT in the field of ADULT NEUROGENESIS is sought at the University of Oxford and the University of Tsukuba
University of Oxford's Department of Physiology, Anatomy and Genetics and the University of Tsukuba's Faculty of Life and Environmental Sciences seek an outstanding and highly motivated Postdoctoral Research Assistant (PDRA) in the field of adult neurogenesis and nutraceuticals. The Isoda lab in Tsukuba and the Szele laboratory in Oxford are collaborating to determine the effects of bioactive food extracts and molecules within them on subventricular zone, subgranular zone and hypothalamic postnatal and adult neurogenesis and gliogenesis. The postdoctoral fellow will use a variety of in vitro assays including neurosphere stem cells to uncover efficacy and cellular mechanism of action. They will use RNAseq, enzyme-based and signaling assays to determine molecular mechanism of action. The second phase of work involves in vivo testing of compounds in animal models of ageing and Alzheimer's disease. In this phase, extensive behavioral analysis will be used to determine the effects of the compounds on cognition and memory.
The postdoctoral fellow will be embedded in the Szele lab at the University of Oxford. The Szele lab seeks to uncover molecular mechanism regulating neurogenesis in health and disease and is actively seeking compounds to regulate SVZ and SGZ stem cell activation for therapy. The Szele group is highly collaborative and interdisciplinary and owns or has access to state-of-the-art facilities and equipment. The Postdoctoral Fellow will also work part time in the Isoda group at the University of Tsukuba - a vibrant Science City 45 minutes north of Tokyo. The postdoctoral fellow will interact with a team of researchers in Tsukuba examining the effects of nutraceuticals from the molecular to the organismal level and also using clinical trials.
One to several trips per annum between the UK and Japan are envisaged. Willingness to travel as well as fluency in English and cross-cultural flexibility are essential pre-requisites for this position. Fluency in Japanese is desirable. The postdoctoral fellow must have obtained a PhD and have significant experience in the following: postnatal or adult neurogenesis, developmental neuroscience, primary neural cell culture (ex. neurospheres), in vivo histological analysis and behavioral assays. These positions are available immediately for 12 months in the first instance, with the possibility of extension for a further 36 months.
For an informal discussion about the post, please contact Professor Francis Szele (Francis.Szele@DPAG.ox.ac.uk) and/or Professor Hiroko Isoda (email@example.com)
Internal Number: 22::22
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Department of Physiology, Anatomy and Genetics
We are home to a large number of internationally-renowned teams of scientists addressing major questions in biomedicine, the answers to which will have a profound effect on modern biology. Crucially, though, we think that learning is just as important as research, and at our core lies a belief that a synthesis of the two is key to advancing our understanding. As such, we work to provide outstanding opportunities for graduate students and post-doctoral workers to gain a research training of the very highest quality, which will enable them to become the leaders of tomorrow and to communicate and employ their research in the wider world.
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