Postdoctoral Position: Interdisciplinary Study of Neurotransmitter Release Mechanisms
April 3, 2018
New York City, New York
Full Time - Entry Level
Academic / Research
Establishing how neurotransmitter release at synapses is regulated in neural circuits for memory storage and complex behavior is a major challenge for neuroscience, and has important implications for treating neurodegenerative and neurodevelopmental disorders. While many of the molecular components of the machinery responsible for membrane fusion and neurotransmitter release have been identified, how they coordinate as a machine remains a mystery. Many fundamental questions remain, such as: by what mechanism do synaptic vesicles and the neuronal plasma membrane form the fusion pore? How are the rates and net amounts of neurotransmitter released through the fusion pore regulated? A postdoctoral position is available for an interdisciplinary project to investigate these questions. This innovative project will combine electrophysiological and mathematical modeling approaches, and will be a collaborative effort between two laboratories in the departments of Pathology & Cell Biology and Chemical Engineering at Columbia University. Applicants should have a recent PhD in neuroscience, biophysics or related field, expertise in single-cell electrophysiological recording and neuronal cell culture, and outstanding oral and written communication skills. Some computational skills and familiarity with mathematical modeling concepts are also preferred.
Columbia University is home to a dynamic and renowned neuroscience community, with experts in all areas (molecular, cellular, developmental, circuit-level, systems, behavioral, and computational) represented within a few blocks’ proximity, creating a rich environment for collaboration and the exchange of ideas. Columbia offers many opportunities for postdocs to expand their knowledge and skills through research seminar series, as well as professional training and development sponsored by the Office of Postdoctoral Affairs. New York City is a diverse and vibrant city with multiple cultural opportunities and close proximity to the outdoors. Together, Columbia and NYC provide an outstanding intellectual environment for the motivated postdoctoral scientist.