Postdoctoral Fellow - Epigenetic Regulation in Neurodegeneration
University of California San Diego
March 29, 2018
San Diego, California
Full Time - Entry Level
Academic / Research
A postdoctoral position is available in Dr. Paula Desplats’ laboratory in the Department of Neurosciences, University of California San Diego.
The Desplats lab is interested in understanding epigenetic deregulation that may contribute to adult neurodegenerative disorders. We apply a variety of models ranging from human postmortem brain samples; transgenic mouse models and primary cell lines to understand disease changes and to decipher mechanisms of gene regulation. Our lab has a long-standing trajectory on unraveling disease mechanisms associated with alpha-synuclein missfolding and accumulation (PNAS 2009, 106(31): 13010-5; JBC 2012 287(38): 31691-702), including pioneering epigenetic analysis in Parkinson’s disease (Epigenetics2013, 8(10): 1030). The candidate postdoc will have the opportunity to work primarily in a new exciting project studying the relation between alterations of dynamic DNA methylation; disruption of circadian rhythms and Alzheimer’s disease pathology, extending our recent studies (Alzheimer’s Dement. 2017, 13(6):689-700). The postdoctoral researcher will also have the opportunity to participate in ongoing related projects in Parkinson’s disease, and is expected to contribute to train undergraduate students rotating in the lab.
We are looking for a self-motivated individual with strong creative and critical thinking; detail-oriented and goal-driven researcher who is an exceptional team player.
If you are interested in joining a growing and vibrant lab with a passion for translational science and to enjoy the highly collaborative neuroscience community of San Diego (and beautiful area and weather), please contact the PI at firstname.lastname@example.org including c.v. and a brief description of research interests.
Recent Ph.D. in neurosciences, molecular or cell biology.
Expertise in transcription and epigenetic analysis.
Experience with mouse models of neurodegeneration is preferred.
Advance skills in tissue culture, including stem cells and primary cell cultures.
A record of high-impact peer-reviewed publications.
Bioinformatics experience and knowledge of sequencing data analysis is a big plus
Excellent writing and oral communication skills.
No more than 2 years of previous postdoctoral experience.
Internal Number: 280318
About University of California San Diego
Research in our lab is aimed at elucidating the dynamic mechanisms of DNA methylation, which might contribute to onset and progression of the most prevalent neurodegenerative diseases of the elderly, Parkinson’s and Alzheimer’s. At the center of our work is a strong interest in translational neuroscience, therefore we combine aspects of cellular physiology and molecular neuroscience, integrating the analysis of human postmortem brain samples, transgenic animals and cellular models to address mechanistic questions, while identifying therapeutic targets and providing novel diagnostic tools.