Postdoctoral Research Fellow - Vanderbilt Center for Neuroscience Drug Discovery
Vanderbilt Center for Neuroscience Drug Discovery
March 28, 2018
Fellowship - Experienced
Academic / Research
Vanderbilt University Department of Pharmacology Vanderbilt Center for Neuroscience Drug Discovery
Postdoctoral Fellow (0-3 years post-graduate experience)
The Niswender lab is seeking an inquisitive and motivated postdoctoral fellow to join our Neurodevelopmental Disorders group within the Vanderbilt Center for Neuroscience Drug Discovery (VCNDD). Students and postdocs within the VCNDD receive exposure to all facets of academic drug discovery, ranging from testing basic science hypotheses, compound development, and translational neuroscience. Our group integrates elements of neuroscience, behavioral and molecular pharmacology, drug metabolism and pharmacokinetics, and electrophysiology to interrogate the role of metabotropic glutamate receptors and muscarinic acetylcholine receptors in autism and autism-associated disorders.
The candidate will work with Dr. Colleen Niswender and several other senior scientists within the VCNDD to design and implement experiments to address questions that are central to our lab's interests and funding. The available projects focus on the role of the mGlu7 receptor in the neurodevelopmental disorder Rett syndrome. Successful candidates will receive training in electrophysiology, behavioral neuroscience, molecular pharmacology as well as manuscript and grant writing, all in the context of a team science-oriented academic drug discovery environment. With time, successful candidates will be encouraged to develop their own hypotheses as well as to solicit their own external funding.
Special consideration will be given to candidates with excellent written and oral communication skills, as well as those who are self-motivated, with ability to work independently.
Please note that this opportunity is for an early stage postdoctoral position. Research faculty positions are not available at present.
Vanderbilt University is committed to principles of equal opportunity and affirmative action.
Graduation from an accredited college or university with a PhD in neuroscience, pharmacology or a related field Minimum of 2 first author publications Ability to work independently, but function as part of a team Excellent written and oral communication skills Highly motivated to learn new techniques, develop hypotheses and obtain autonomous funding
Desired or preferred-Experience with any of the following:
Standard molecular biology techniques Knowledge of mouse genetics Brain slice electrophysiology Knowledge of neurobehavioral assays Experience formulating compounds is required
Specific Position Duties with Percentages of Time
[ 90 ]% Techniques used in this position include, but are not limited to:
Mouse breeding and genetic manipulation Post-mortem rodent surgery Biochemical analysis of rodent brains Preparation of brain slices from rodents Electrophysiological recordings from brain slices Neurobehavioral phenotyping in rodents Cell culture Molecular cloning In vitro and in vivo assessment of compound efficacy Data analysis (knowledge of Microsoft Office, Excel, and Graphpad Prism are a prerequisite) Presentation of data at meetings both internal and external to the VCNDD Detailed maintenance of all required notebooks and compound log sheets
***It is not anticipated that the candidate will have experience in all of the above techniques. Some degree of training is anticipated.
[ 10 ]% Supervision of research assistants, graduate students and undergraduate researchers
Assure trainees adhering to standard lab practice Mentor career development of junior trainees
Application Materials Required:
Cover letter Research statement (not to exceed 2 pages) Contact information of 3 professional references Resume/CV
Salary and Benefits:
Salary is commensurate with skills and experience.
Please be advised that Vanderbilt University does check references as part of the employment process.
Internal Number: CMN1
About Vanderbilt Center for Neuroscience Drug Discovery
Housed within the walls of Vanderbilt University and the Department of Pharmacology, The Vanderbilt Center for Neuroscience Drug Discovery (VCNDD) extends traditional academic pursuits in basic science to take the most exciting advances in our understanding of human disease and drug targets to a point where these breakthroughs have the potential to directly impact patient care. The most innovative and potentially high impact new approaches for treatment of human disease that arise from academic basic science efforts are often untested and pose unacceptable risks for investment of the tremendous capital required to discover and develop a new drug in an industry setting. This is especially true in discovery of new treatment strategies for the most serious of brain disorders, such as Alzheimer’s disease, Parkinson’s disease, schizophrenia, autism, and others. By incorporating the highest level of drug discovery into academic research, we are able to advance the most exciting scientific breakthroughs beyond the lab and toward the development of patentable and marketable drugs suited for clinical studies.
The Vanderbilt Center for Neuroscience Drug Discovery is staffed by dozens of ...scientists, most of which bring industry experience to this collaborative, academic setting. Since 2007, VCNDD has made significant progress in finding treatments and possible cures for neurological disorders such as Fragile X syndrome, schizophrenia, dystonia, Parkinson’s disease, Alzheimer’s disease, and post-traumatic stress disorder. VCNDD research has been funded publicly by the NIMH, NIDA, and NINDS, as well as privately by the Michael J Fox Foundation, Seaside Therapeutics, Johnson & Johnson, Astra Zeneca, Lundbeck, and other foundation and corporate partners.