The Neuroscience Lead (or CNS) will manage the CNS functional group within the Discovery Research group under Translational Research. He/she will be responsible for:
• Providing leadership within a group of scientists/research associates, to develop pre-clinical programs from early discovery to the clinic.
• Initiate and oversee joint programs with academic collaborators.
• Establishing project timelines and ensuring work is completed according to schedule.
• Training and developing staff at varying levels of experience.
The CNS Preclinicnal Lead position requires extensive translational experience with CNS gene therapies, including;
• In-depth knowledge of neurodegenerative disorders.
• Experience with delivery techniques targeting the central nervous system such as intracranial injections and have substantial experience with studies in laboratory animals.
• Familiarity with target validation and lead identification/optimization, using a combination of molecular, cellular and in vitro/in vivo techniques for CNS gene therapy programs.
• Some familiarity with AAV, as well as some knowledge of clinical trial design and regulatory strategy, is preferred.
20% Hands-on execution of experiments on the bench
40% Identify and validate new indication targets. Design and trouble-shoot experiments based on personal experience and literature review. Prepare and deliver scientific presentations at internal and external meetings
20% Prioritize projects, plan workload, manage resource and personnel scheduling
10% Preparing sample analysis reports and write parts of regulatory submissions to FDA
10% Lead a team of scientists. Mentor and develop staff.
Ensure departmental goals and objectives are met and aligned to the broader organizational goals and objectives.
• Extensive hands-on experience in CNS/neurodegenerative disease models and manipulations, such as intracerebroventricular and intraparenchymal injections, with experience in CNS gene therapy preferred.
• Strong organizational skills.
• Excellent writing and verbal communication skills.
• Previous management experience preferred, but not required.
• Strong publication record is a plus.
• Experience with AAV vectors is a plus.
• Demonstrate independent problem solving skills of technical issues; develop solutions to a variety of moderate to complex problems. Discuss with supervisor and refer to policies/practices for guidance.
• Must be comfortable in the fast-paced, biotech start-up environment and interact with multi-disciplinary research teams at Spark.
• Exercise judgment within defined procedures and practices to determine appropriate action.
• Ph.D. in relevant scientific discipline (e.g. cell and molecular biology, biochemistry, etc.)
• Minimum 5-8 years of hands-on experience in the field of gene therapy for neurodegenerative disorders.
• Previous management or supervisory experience strongly preferred.
Internal Number: CNSLEAD
About Spark Therapeutics
Founded in March 2013 as a result of the technology and know-how accumulated over two decades at Children’s Hospital of Philadelphia (CHOP), Spark Therapeutics is a publicly traded, late clinical-stage gene therapy company. Its investigational therapies have the potential to provide long-lasting effects, dramatically and positively changing the lives of patients with conditions where no, or only palliative, therapies exist. Greater understanding of the human genome and genetic abnormalities have allowed our scientists to tailor investigational therapies to patients suffering from very specific genetic diseases. This approach holds great promise in developing effective treatments to a host of inherited diseases. Our initial focus is on treating orphan diseases.
Headquartered in dynamic Philadelphia, we are a diverse, experienced team united in our goal to break down barriers for people and families affected by genetic diseases. As our name suggests, our investigational, one-time therapies are designed to spark healthy biology, and deliver potentially life-altering transformation for people and families affected by genetic disease.
Challenge the inevitability of geneti...c disease by discovering, developing and delivering treatments in ways unimaginable – until now.
A world where no life is limited by genetic disease.