Post-Doctoral Fellowship for Genomic Toxicology at NCATS
National Institutes of Health
February 20, 2018
Full Time - Experienced
Academic / Research
Position Description: A Postdoctoral Position is needed to implement new methods and assays to enable screening of chemical libraries to identify toxicants for the Tox21 Consortium and drug candidates for NCATS programs.
Background: The Genomic Toxicology Laboratory participates in the Tox21 Consortium by developing methods for assessing the effects of chemicals on human health. This lab is currently developing novel methods for gene expression profiling and data analysis, as well as improving cell culture models that include 3D culture, stem cells and immortalized cells. One novel method quantitates the expression of selected genes in hundreds of thousands of cultured human cell samples. The unprecedented throughput of this method will enable screening of large chemical libraries of environmental toxicants or drug candidates. Our accompanying Point-of-Departure analytical method also enables quantitative characterization of the dose-response relationships that are the basis of toxicology and pharmacology. Because quantitative high-throughput screening of large chemical libraries (qHTS) is the core expertise of NCATS, there are pervasive needs and abundant collaborative opportunities to apply this method to identify drug candidates and to repurpose existing drugs, as well as to screen Tox21 toxicant libraries. Initially, we plan to screen toxicant libraries by assaying human genes to address cell stress pathways as well as apoptosis and cell growth arrest endpoints.
The Genomic Toxicology Lab collaborates with the Chemoinformatics group and the Systems Toxicology Lab in NCATS to support the Tox21 Consortium, which is a federal collaboration among NCATS, NIEHS, EPA, and FDA. Within the NCATS’ Division of Pre-Clinical Innovation, we are assisted by core group experts dedicated to data analysis, stem cell biology, compound library management, robotics and engineering, licensing, et al. NCATS’ Division of Pre-Clinical Innovation is an assay development, ultrahigh-throughput screening and chemistry center which discovers chemical probes of protein and cell functions. The scope of this translationally-focused resource is unparalleled outside of large, proprietary pharmaceutical facilities. It develops new paradigms to enable chemical genomics and develops chemical starting points for new drugs for rare genetic and orphan diseases. The work enables, but is not constrained by, the demands of future commercialization. Located 10 minutes north of the NIH Campus in Rockville, MD, the Center has a staff of over 60 biologists, chemists, engineers, and informatics scientists, who work with investigators throughout NIH and the world to translate the genome into biological function and therapeutics.
Job Description: The post-doctoral fellow will be responsible for the development of screening projects using high-throughput gene expression by applying this method collaboratively to screen for toxicants and drug leads. The Fellowship will therefore provide an ideal career development opportunity for researchers with interests in toxicology, pharmacology, and genomics research. Research will be conducted in the internationally recognized laboratory of Dr. David Gerhold, Head of Genomic Toxicology. Successful candidates must be able to integrate multiple NIH resources including molecular genetics, robotic screening, cell culture, and genome engineering. Proficiency in molecular biology mammalian cell culture systems is required. A background in toxicology and strong prior publications are considered an advantage. Responsibilities will include:
Optimization and implementation of high-throughput gene expression technology.
Utilization of high-throughput, robotic automation of microplate and liquid handling.
Data analysis and drafting of publications and presentations.
Coordination and collaboration with informatics scientists, chemists, engineers, and biologists in a team-based effort.
Effective communication skills to share findings to both technical and non-technical audiences.
Applicants must be US citizens, legal residents, or possess a valid work permit, in order to be considered for the position. Applicants should send their CV including bibliography, and arrange for three letters of reference to be sent to: NCATSgenomictox@mail.nih.gov.
Employer Name: National Center for Advancing Translational Sciences (NCATS)
Position Location (city and state OR city and country if outside the US): Rockville, MD
Application Deadline Date: until the position is filled
Internal Number: 18-002701
About National Institutes of Health
National Institutes of Health-National Center for Advancing Translational Sciences (NCATS)