Postdoctoral Position on Mechanisms of Stress Resilience
November 3, 2017
40000.00 - 43000.00
Fellowship - Experienced
Academic / Research
Position available immediately for a talented postdoctoral fellow to join the laboratory of Dr. William F. Colmers at the University of Alberta in Edmonton, Alberta, Canada, as part of an ongoing, NIH-funded collaboration with Dr. Janice H. Urban of the Chicago Medical School, Rosalind Franklin University, North Chicago, IL.
The project focuses on mechanisms of stress resilience induced in the basolateral amygdala of male and female rats. Previous work in male rats has characterized prolonged physiological and structural changes in BLA PNs which long outlast several repeated treatments of the BLA with NPY, changes which can be replicated in organotypic slice culture (OTC) preparations. The current work will extend these mechanisms to female animals and investigate naturally-occurring models of resilience. The work heavily involves the use of electrophysiology in acute and organotypic brain slices to assess the electrophysiological properties of BLA principal neurons (PNs) and their responses to Neuropepetide Y (NPY) and corticotropin releasing hormone (CRH). In vivo work will consist of stereotaxic implantation of guide cannulae for local microinjections of peptides and drugs into the BLA and measurement of the stress-related behaviors.
You will receive training in brain slice electrophysiology in the Colmers laboratory. Initial work involves electrophysiological recordings from PNs in acute slices from BLA in female rats to characterize acute responses to NPY and CRF to complement ongoing research using OTC cultures of female rats. Training in in vivo methods, including stereotaxic surgery, drug and tracer injections and behavioral assays, will follow.
Applicant must have Ph.D. or equivalent, which must include significant and relevant basic science training at both the undergraduate and graduate level. Training must include extensive experience with in vitro preparations. Experience with intracellular electrophysiology is preferred. Send current CV and arrange for 3 letters of reference. At least one reference letter must be from a faculty member at a North American, European or Australian institution of higher learning. Salary will be based on the University of Alberta scale, and will be commensurate with experience.
Additional Salary Information: University-mandated benefits are included