Postdoctoral Fellow Position at University of California, San Diego

Employer
University of California, San Diego
Location
San Diego, California
Salary
UCSD standard salary scale commensurate with experience
Closing date
Mar 5, 2024

Job Details

A postdoc position is available at University of California, San Diego to study the molecular and cellular mechanisms of the assembly, function, maintenance and aging of glutamatergic synapses in the developing and adult central nervous system in health and in neurodegenerative and neuropyschiatric disorders. We are taking a number of approaches, including CRISPR-Cas9-based gene editing, single cell transcriptomics, single cell epigenomics, spatial transcriptomics, mass spectrometry, protein-protein interactions, super resolution microscopy, tissue clearing, light sheet microscopy, viral tracing of circuits, electrophysiology, and behavioral assays. Skills and experience in molecular and cellular approaches are preferred.

Please contact Yimin Zou (yzou@ucsd.edu)

 

 

 

Company

Yimin Zou's lab at University of California, San Diego studies axon guidance, synapse formation, injury and repair of the central nervous system. We are interested in axon guidance cues that provide directional information and identified the Wnt family proteins as key guidance molecules along the major axes of the central nervous system for axon pathfinding and topographic mapping. We are currently studying how these guidance cues are laid out in concentration gradients and how axonal growth cones recognize and respond to these gradients. We found that the conserved apical-basal and planar cell polarity pathways mediate growth cone turning and an apical-basal polarity signaling component, aPKC, promotes the endocytosis of a Wnt/planar cell polarity component, Frizzled3. We are testing whether this is part of an amplification mechanism for asymmetric signaling to polarize growth cones. Traumatic injuries of the adult brain and the spinal cord lead to loss of many important functions. We found that the Wnt signaling pathways are reactivated after spinal cord injury. The reinduced Wnt inhibitory system limits the sprouting of corticospinal tract collateral branches and regenerative growth of sensory axons and thus inhibits functional recovery. Our recent studies showed that combining molecular manipulation to enhance axon plasticity with behaviorally-guided training lead to the maximal functional recovery. We are currently studying the network basis of neural circuit remodeling after spinal cord injury. The signaling mechanisms that assemble neuronal synapses have been elusive. Our recent finding suggests that planar cell polarity signaling components play essential roles in glutamatergic synapse formation. This opens up new opportunities to better understand synaptogenesis and plasticity, fundamental to neural circuit function and diseases. We recently received a collaborative BRAIN Initiative grant to characterize all spinal cord neurons that are connected with various structures of the brain by single cell transcriptomics, morphology, electrophysiology and connectivity. My lab has extensive experience in studying the development and function of many neuronal cell types, including cortical and hippocampal neurons, retinal ganglion cells, spinal cord commissural neurons, spinal cord motor neurons and dorsal root ganglion neurons. We perform organotypic or dissociated cultures to study molecular and cellular mechanisms using advanced imaging techniques, such as super resolution microscopy (STORM). We are experienced with knockout and transgenic approaches and are applying the CRISPR-Cas9 system in many of our studies. We incorporate proteomics and transcriptome analyses as part of our strategies. We carry out behavior studies, electrophysiology and optogenetics and recently started two-photon imaging of dendritic spines and calcium imaging of awake behaving animals with both two-photon microscope and miniature microscope.

Apply for Postdoctoral Fellow Position at University of California, San Diego

Fields marked with an asterisk (*) are required

Your file must be a .doc, .pdf, .docx, or .rtf. No larger than 1MB
Selected file:

Find out more about TopResume

When you apply for a job we will send your application to the named employer, who may contact you. By applying for a job listed on NeuroJobs Career Center you agree to our terms and conditions and privacy policy. You should never be required to provide bank account details. If you are, please contact us. All emails will contain a link in the footer to enable you to unsubscribe at any time.

Get job alerts

Create a job alert and receive personalized job recommendations straight to your inbox.

Create alert