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Postdoctoral fellow

Bethesda, Maryland
Closing date
Feb 16, 2024

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Job Details

Job title: Postdoctoral position (Lee Lab, Unit on Functional Neural Circuits)

Employer: National Institute of Mental Health (NIMH), National Institutes of Health (NIH)

Location: Bethesda, Maryland, USA

Description: A postdoctoral position is available in Lee lab (Unit on Functional Neural Circuits). 

My lab studies the organization of neural circuits that enable corticocortical communication and support the computations of dynamic interactions between sensory and behavioral functions using rodents and non-human primate (marmoset). To comprehend how the neocortex integrates and contextually computes relevant incoming information, a mechanistic understanding of the recruitment and role of the various cellular and circuit elements within the corticocortical communication is imperative. We aim 1) to unravel the circuit mechanisms, at a neuronal resolution, through which diverse internal states are transmitted and integrated in relevant brain areas, 2) to determine the behavioral significance of these circuits, 3) to understand the computations they perform, and 4) to explore how such circuit mechanisms emerge during development and adapt through experiences. We focus on motor-sensory processing in somatosensory cortex and connected brain areas of the mouse. We use a combination of methods, including diverse imaging, in vitro and in vivo electrophysiological recordings, optogenetics, chemogenetic, genetic labelling and anatomical tracing, genetic analysis and computational analysis. 

We are looking for highly talented and motivated postdoctoral fellows who have a MD/PhD or PhD in Neuroscience or related disciplines and who have a record of research productivity. We are particularly interested in candidates who have strong quantitative and programming skills and experience in at least one of the following tools: imaging, electrophysiology (in vitro and/or in vivo), and behavioral study. Scientific creativity and communication skills are also important as the candidates will work both independently and as part of a team. Salary will be commensurate with education and experience.

Start date: flexible




From Lee Lab

  1. Inacio AR, Lam KC, Zhao Y, Pereira F, Gerfen CR, Lee S. Distinct brain-wide presynaptic networks underlie the functional identity of individual cortical neurons  bioRxiv 2023.05.25.542329. PMID: 37425800 (under revision) Rhodes CT, Asokumar D, Sohn M, Naskar S, Elisha L, Stevenson P, Lee DR, Zhang Y, Rocha PP, Dale RK, Lee S, Petros TJ. Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles bioRxiv 2023.09.06.556544 (under review) Naskar S, Inacio AR, Stevenson P, Qi J, Lee S. Development of cortical disinhibitory circuit (under review) Naskar S, Stevenson P, Ye C, Qi J, Lee S. Reduction of SynGAP1 in cortical Parvalbumin-positive GABAergic neurons impairs long-range cortico-cortical connectivity. (under review) Qi J, Ye C, Naskar S, Inácio AR, Lee S. Posteromedial thalamic nucleus activity significantly contributes to perceptual discrimination. PLoS Biol. 2022 Nov 28;20(11):e3001896. PMID: 36441759  Jung WB, Jiang H, Lee S, Kim SG. Dissection of brain-wide resting-state and functional somatosensory circuits by fMRI with optogenetic silencing. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2113313119. PMID: 35042795 Zagha E, Erlich JC, Lee S, Lur G, O'Connor DH, Steinmetz NA, Stringer C, Yang HJ. The importance of accounting for movement when relating neuronal activity to sensory and cognitive processes. Journal of Neuroscience. 2022 Jan 6:JN-TS-1919-21. PMID: 35027407 Naskar S, Qi J, Pereira F, Gerfen CR and Lee S. Cell-type-specific recruitment of GABAergic interneurons in the primary somatosensory cortex by long-range inputs. Cell Reports. 2021 Feb 23;34(8):108774. doi: 10.1016/j.celrep.2021.108774, PMID: 33626343


From previous works

  1. He M, Tucciarone J, Lee S, Nigro MJ, Kim Y, Levine JM, Kelly SM, Krugikov I, Wu P, Chen Y, Gong L, Hou Y, Osten P, Rudy B, Huang ZJ. Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex. Neuron 91(6):1228-43, 2016. PMID: 27618674 Tremblay R, Lee S, Rudy B. GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits. Neuron 91(2):260-92, 2016. PMID: 27477017 Lee S, Kruglikov I, Huang J, Fishell G, Rudy B. A disinhibitory circuit mediates motor integration in the somatosensory cortex. Nature Neuroscience 16(11):1662-70, 2013. PMID: 24097044 Rudy B, FIshell G, Lee S, Hjerling-Leffler J. Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons. Dev. Neurobiol. 71(1):45-61, 2011. PMID: 21154909 Lee S, Hjerling-Leffler J, Zagha E, Fishell G, Rudy B. The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors. Journal of Neuroscience 30(50):16796-808, 2010. PMID: 21159951 Lee S, Carvell G, Simons DJ. Motor modulation of afferent somatosensory circuits. Nature Neuroscience 11(12):1430-8, 2008. PMID: 19011625



The NIH is home to one of the largest neuroscience research centers in the world. Over 150 laboratories, originating from eleven different Institutes, conduct research in the basic, translational, and clinical neurosciences. Through scientific collaboration, Pre- and Postdoctoral Training Programs, jointly sponsored Seminar Series and Special Interest Groups, scientists at NIH contribute to a vital and growing neuroscience research community. NIMH researchers conduct research ranging from studies into mechanisms of normal brain function, conducted at the behavioral, systems, cellular, and molecular levels, to clinical investigations into the diagnosis, treatment and prevention of mental illness. NIH and DHHS are equal opportunity employers.

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