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Postdoctoral Fellow to Study the Cerebellum

Harvard Medical School
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts
Standard HMS postdoc salaries.
Closing date
Dec 10, 2023

Seeking postdoctoral fellows to study the cerebellum. Areas of investigation include: characterization of cell types in the cerebellar cortex, characterization of cerebellar circuitry, determination of the roles of the cerebellum in motor and social behaviors, and characterization of novel cerebellar outputs. Techniques used include: slice electrophysiology, in vivo multielectrode recordings, calcium measurements, AAV manipulation, optogenetics, mouse genetics, immunofluorescence, FISH, multielectrode recording in awake behaving animals, behavioral analysis (including many social behaviors, gait analysis, Motion Seq, VOR and conditioned eyeblink), serial electron reconstructions (in collaboration with the Lee lab), snRNAseq (in collaboration with the Makosco lab), and in vivo 2-photon functional imaging. The ideal candidate should be creative, able to both lead their own independent project, and able to work with others on collaborative projects. At present there are multiple areas of immediate interest:

1. There is an opportunity to use slice recording techniques to study cerebellar circuitry.  The successful applicant will have access to numerous transgenic mice to target specific cell types and subtypes in the cerebellar cortex. A devoted setup with whole cell recording combined with two photon imaging will be available. Experience in slice electrophysiology is highly desirable for this position. Representative papers are available on the lab website.

2. EM reconstructions and connectomics of the cerebellar cortex.  EM reconstructions are increasingly used to complement slice and in vivo studies of different types and subtypes of cerebellar neurons.  The ability to program in Python and Matlab is essential, and experience in connectomics is desirable.  This is part of a longstanding collaboration with Wei-Chung Allen Lee. 


3. Molecular approaches to studying the cerebellar cortex. We have a longstanding collaboration with Evan Macosko that began with our snRNAseq characterization of cell types in the cerebellum.  Many related questions remain regarding the cells of the cerebellar cortex, and the cells that provide inputs to the cerebellum and the cells that are targeted by cerebellar Purkinje cells.  


Please email a cover letter, a curriculum vitae, and names & email addresses of three references to:
Wade G. Regehr
Department of Neurobiology
Harvard Medical School
Goldenson 307
Boston, MA 02115


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